[雄性Wistar大鼠甲状腺放射性碘消融剂量的估计]
[Estimate of the dosage for radioiodine ablation of the thyroid gland in male Wistar rats].
作者信息
Hanauer G, Schroth H J
机构信息
Institut für Veterinär-Physiologie Justus-Liebig-Universität Giessen.
出版信息
Zentralbl Veterinarmed A. 1990 Dec;37(10):747-51.
The aim of this investigation was to determine the radioiodine dose necessary for the ablation of the thyroid gland in male Wistar rats. By a mathematical extrapolation of the kinetics of iodine-131, the radioisotope dose in the thyroid was calculated to be 467971 or 401540 rad after an intraperitoneal administration of 1 x 0.8 mCi (29.6 MBq) or 1 x 1.0 mCi (37.0 MBq) iodine-131, respectively. Because lower radioiodine activities did not result in a complete destruction of the thyroid (controlled by scintigraphic methods), it can be concluded that about 400,000 rad are necessary for the complete ablation of the thyroid gland by radioiodine.
本研究的目的是确定雄性Wistar大鼠甲状腺消融所需的放射性碘剂量。通过对碘-131动力学进行数学外推，腹腔注射1×0.8毫居里（29.6兆贝可）或1×1.0毫居里（37.0兆贝可）碘-131后，甲状腺中的放射性同位素剂量经计算分别为467971拉德或401540拉德。由于较低的放射性碘活度不会导致甲状腺完全破坏（通过闪烁扫描法控制），可以得出结论，通过放射性碘完全消融甲状腺大约需要400,000拉德。
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