硝酸甘油对犬基底动脉中稳定的血栓素A2类似物诱导的、硝苯地平抵抗性收缩的影响。

Effects of nitroglycerin on stable thromboxane A2 analogue-induced, nifedipine-resistant contraction in canine basilar artery.

作者信息

Usui H, Akimoto Y, Kurahashi K, Shirahase H, Fujiwara M, Shibata S, Suzuki A

机构信息

Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan.

出版信息

Jpn J Pharmacol. 1990 Oct;54(2):237-40. doi: 10.1254/jjp.54.237.

DOI:10.1254/jjp.54.237

PMID:2127613

Abstract

The stable thromboxane A2 analogue, STA2, caused concentration-dependent contractions in the canine basilar artery. In Ca2(+)-free medium containing EGTA (0.1 mM) and nifedipine (10(-6) M), the addition of Ca2+ (2.5 mM) in the presence of STA2 (10(-8) M) caused a tonic contraction (nifedipine-resistant Ca2(+)-induced contraction). In the basilar artery, nitroglycerin did not significantly affect such nifedipine-resistant Ca2(+)-induced contractions, but nearly abolished the contraction in the coronary artery. The present experiments suggest that the regulatory mechanism of mobilized Ca2+ for the nifedipine-resistant Ca2(+)-induced contraction produced by STA2 in the basilar artery is different from that in the coronary artery.

摘要

稳定的血栓素A2类似物STA2可引起犬基底动脉浓度依赖性收缩。在含有EGTA（0.1 mM）和硝苯地平（10^(-6) M）的无钙培养基中，在STA2（10^(-8) M）存在的情况下添加Ca2+（2.5 mM）会引起强直性收缩（硝苯地平抵抗性Ca2+诱导的收缩）。在基底动脉中，硝酸甘油对这种硝苯地平抵抗性Ca2+诱导的收缩没有显著影响，但几乎完全消除了冠状动脉中的收缩。本实验表明，STA2在基底动脉中产生的硝苯地平抵抗性Ca2+诱导收缩所涉及的动员Ca2+的调节机制与冠状动脉中的不同。