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多学科团队方法在原发性上皮性卵巢癌患者肝门部肿瘤扩大细胞减灭术中的应用。

Extended cytoreduction of tumor at the porta hepatis by an interdisciplinary team approach in patients with epithelial ovarian cancer.

机构信息

Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-769, Republic of Korea.

出版信息

Gynecol Oncol. 2011 May 1;121(2):253-7. doi: 10.1016/j.ygyno.2010.12.350. Epub 2011 Jan 28.

Abstract

OBJECTIVE

The objective of this study was to describe the development and experience in resection of tumor at the porta hepatis in patients with ovarian cancer by an interdisciplinary team approach.

METHODS

From August 2007 to June 2009, 11 women (2 primary and 9 recurrent ovarian cancers) underwent extended cytoreductive surgery including resection of tumor at the porta hepatis by hepatobiliary surgeons.

RESULTS

Tumor resection at the porta hepatis was required in 7.1% of the patients (11/155) during the study period. The median tumor size of the porta hepatis was 2.0cm (range, 0.7-4cm). All visible tumors at the porta hepatis were completely resected with co-operation of hepatobiliary surgeons. Optimal cytoreduction was achieved in all patients. There was no significant morbidity related to tumor resection of the porta hepatis and mortality associated with surgery. Five of 11 patients had recurrent disease at median 8months (range, 1-13) after the surgery with a median follow-up of 8months (range, 3-21months).

CONCLUSION

Tumor resection at the porta hepatis is feasible with acceptable morbidities in patients with ovarian cancer by an interdisciplinary team approach with hepatobiliary surgeons. Long term follow up is needed to know the impact on survival.

摘要

目的

本研究旨在描述由多学科团队进行的肝门部肿瘤切除术的发展和经验,该手术适用于卵巢癌患者。

方法

2007 年 8 月至 2009 年 6 月,11 名女性(2 例原发性和 9 例复发性卵巢癌)接受了由肝胆外科医生进行的广泛减瘤手术,包括肝门部肿瘤切除术。

结果

在研究期间,有 7.1%(11/155)的患者需要进行肝门部肿瘤切除术。肝门部肿瘤的中位大小为 2.0cm(范围,0.7-4cm)。所有可见的肝门部肿瘤均在肝胆外科医生的协作下完全切除。所有患者均达到了最佳的肿瘤减灭术效果。肝门部肿瘤切除术无明显与手术相关的发病率和死亡率。11 名患者中有 5 名在术后中位时间 8 个月(范围,1-13)时复发,中位随访时间为 8 个月(范围,3-21 个月)。

结论

通过多学科团队(包括肝胆外科医生)的方式,卵巢癌患者的肝门部肿瘤切除术是可行的,且具有可接受的发病率。需要长期随访以了解对生存的影响。

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