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通过Y形导管连接两种不同pH值的全胃肠外营养制剂给药时阿米卡星和环丙沙星的体外稳定性

[In vitro stability of amikacin and ciprofloxacin administered through a Y-shaped catheter connection with 2 total parenteral nutrition formulations with different pH].

作者信息

Balet A, Cardona D, Pastor C, Márquez M

机构信息

Servicio Farmacia, Hospital Sta. Creu i St. Pau., Barcelona.

出版信息

Nutr Hosp. 1990 Mar-Apr;5(2):108-11.

PMID:2127703
Abstract

We studied the stability of amikacin and ciprofloxacin in in vitro coinfusion with two total parenteral nutrition. The antibiotic concentrations were determined by EMIT and HPLC for amikacin and ciprofloxacin, respectively. There were not significant differences between theoretical and measured concentrations. The emulsion stability were analyzed by visual inspection, Coulter-Counter and optic microscopy. The emulsion was stable and we didn't find any particle of size greater than 6 microns.

摘要

我们研究了阿米卡星和环丙沙星与两种全胃肠外营养制剂在体外联合输注时的稳定性。分别采用酶放大免疫测定技术(EMIT)和高效液相色谱法(HPLC)测定阿米卡星和环丙沙星的抗生素浓度。理论浓度和实测浓度之间没有显著差异。通过肉眼观察、库尔特计数器和光学显微镜分析乳液稳定性。乳液稳定,我们未发现任何粒径大于6微米的颗粒。

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