亚抑菌浓度头孢噻肟抑制泌尿道致病性大肠埃希菌黏附导管。
Inhibition of the adhesion to catheters of uropathogenic Escherichia coli by sub-inhibitory concentrations of cefotaxime.
机构信息
Area Bacteriología, Departamento de Microbiología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, Rosario 2000, Santa Fe, Argentina.
出版信息
Eur J Obstet Gynecol Reprod Biol. 2011 Apr;155(2):150-6. doi: 10.1016/j.ejogrb.2010.12.034. Epub 2011 Jan 28.
OBJECTIVE
To investigate the effect of sub-inhibitory concentrations of cefotaxime on adherence to siliconized latex urinary catheters of uropathogenic Escherichia coli strains from pregnant and non pregnant patients.
STUDY DESIGN
Using random sampling, 30 E. coli strains were selected from hospitalized patients with catheter associated urinary tract infection, 12 from pregnant women and 18 from men and non-pregnant women. The strains were categorized on the basis of cefotaxime susceptibility, adhesion and biofilm production capacity, cell surface hydrophobicity and expression of adhesins and fimbriae in vitro.
RESULTS
The overall results indicated that sub-inhibitory concentrations of cefotaxime could reduce the adhesiveness, the biofilm production and hence, potentially, the infection rate associated with indwelling urinary catheters.
CONCLUSION
Based on our results, we propose that this reduction is due to decreasing exopolysaccharide production and increasing cell surface hydrophobicity of E.coli strains.
目的
研究头孢噻肟亚抑菌浓度对妊娠和非妊娠患者尿路感染大肠埃希菌菌株黏附硅化乳胶导尿管的影响。
研究设计
采用随机抽样的方法，从住院患者的导管相关性尿路感染中选择了 30 株大肠埃希菌，其中 12 株来自孕妇，18 株来自男性和非妊娠女性。根据头孢噻肟的药敏性、黏附性和生物膜生成能力、细胞表面疏水性以及体外黏附素和菌毛的表达，对菌株进行了分类。
结果
总体结果表明，头孢噻肟的亚抑菌浓度可以降低黏附性、生物膜生成能力，从而降低与留置导尿管相关的感染率。
结论
根据我们的结果，我们提出这种减少是由于大肠杆菌菌株胞外多糖生成减少和细胞表面疏水性增加所致。
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