Toren Kristen L, Parlette Eric C
Department of Dermatology, Walter Reed Army Medical Center, Washington, DC, USA.
Semin Cutan Med Surg. 2010 Dec;29(4):258-63. doi: 10.1016/j.sder.2010.10.002.
Melanoma is a highly aggressive skin cancer with an increasing incidence. Melanoma in situ is an early, non-invasive form in which the tumor is confined to the epidermis. Treatment of melanoma in situ is challenging due to the frequent subclinical microscopic spread and to the presentation on the head and neck in cosmetically sensitive areas with chronic sun damage. Optimizing tumor eradication is imperative to reduce the potential progression into invasive disease and metastasis, all while maintaining cosmesis. Multiple treatment regimens have been implemented for managing difficult melanoma in situ tumors. We provide a thorough review of surgical, and non-surgical, management of melanoma in situ which can pose therapeutic dilemmas due to size, anatomic location, and subclinical spread.
黑色素瘤是一种侵袭性很强的皮肤癌，发病率呈上升趋势。原位黑色素瘤是一种早期的非侵袭性形式，肿瘤局限于表皮。由于频繁的亚临床微小扩散以及在头颈部等存在慢性阳光损伤的美容敏感区域出现，原位黑色素瘤的治疗具有挑战性。优化肿瘤根除对于减少潜在进展为侵袭性疾病和转移至关重要，同时还要保持美观。已经实施了多种治疗方案来管理难处理的原位黑色素瘤肿瘤。我们对原位黑色素瘤的手术和非手术管理进行了全面综述，这些原位黑色素瘤由于大小、解剖位置和亚临床扩散可能会带来治疗难题。
