Molecular Medicine Center and Department of Medical Chemistry and Biochemistry, Medical University - Sofia, Sofia 1431, Bulgaria.
Drug Alcohol Depend. 2011 Aug 1;117(1):62-5. doi: 10.1016/j.drugalcdep.2010.12.026. Epub 2011 Jan 31.
The μ-opioid receptor is the primary site of action of most opioids. The 118A>G (rs1799971) polymorphism in exon 1 of the μ-opioid receptor gene (OPRM1) leads to an Asn40Asp amino acid change that affects a putative N-glycosylation site. It has been widely investigated for association with alcohol and drug dependence and pain sensitivity, with mixed results. The aim of the current study was to examine whether this polymorphism was associated with heroin dependence in a large Bulgarian cohort of 1842 active users and 1451 population controls. SNP genotyping was done using Real-Time PCR TaqMan technology. Association analyses were conducted, separately for Roma and non-Roma participants. Our results suggest that there is no direct effect of 118A>G genotype on the risk for heroin dependence among active heroin users.
μ-阿片受体是大多数阿片类药物的主要作用部位。μ-阿片受体基因（OPRM1）外显子 1 中的 118A>G（rs1799971）多态性导致天冬酰胺 40 到天冬氨酸的氨基酸变化，影响潜在的 N-糖基化位点。该多态性已广泛研究与酒精和药物依赖和疼痛敏感性的关联，但结果不一。本研究的目的是在一个由 1842 名活跃使用者和 1451 名人群对照组成的大型保加利亚队列中，检查该多态性是否与海洛因依赖相关。SNP 基因分型使用实时 PCR TaqMan 技术进行。分别对罗姆人和非罗姆人参与者进行了关联分析。我们的结果表明，118A>G 基因型对活跃海洛因使用者的海洛因依赖风险没有直接影响。
