Saigo K, Yoshida A, Sugano W, Ryo R, Yamaguchi N
Section of Internal Medicine, Kobe Kyodo Hospital.
Rinsho Ketsueki. 1990 Dec;31(12):1914-9.
Serum or plasma histidine-rich glycoprotein (HRGP) levels were determined in several conditions. In normal volunteers, HRGP levels did not correlate with either plasminogen contents or plasminogen activity, although HRGP has been believed to be a modulator for fibrinolysis system. In acute inflammation, HRGP levels in serum changed as a negative acute phase reactant, which was also confirmed after surgical operation. At the time of demonstrating decreased HRGP values, expression of HRGP fragment was studied using heparin-Sepharose beads. However, no new fragments were detected, suggesting that the decrease was not due to enzymatic destruction. On the other hand, in patients with rheumatoid arthritis (chronic inflammation), HRGP levels were similar to those in control subjects. As HRGP is a potent heparin antagonist, HRGP levels in plasma during hemodialysis with heparin were studied. Both levels of HRGP and albumin increased after hemodialysis in a similar degree due to concentration, indicating that turnover of HRGP was not altered in short period after heparin administration.
在多种情况下测定了血清或血浆中富含组氨酸的糖蛋白（HRGP）水平。在正常志愿者中，尽管HRGP被认为是纤维蛋白溶解系统的调节剂，但其水平与纤溶酶原含量或纤溶酶原活性均无相关性。在急性炎症中，血清中的HRGP水平作为负急性期反应物发生变化，这在手术后也得到了证实。在HRGP值降低时，使用肝素 - 琼脂糖珠研究了HRGP片段的表达。然而，未检测到新的片段，这表明降低并非由于酶促破坏。另一方面，在类风湿性关节炎（慢性炎症）患者中，HRGP水平与对照组相似。由于HRGP是一种有效的肝素拮抗剂，因此研究了肝素血液透析期间血浆中的HRGP水平。血液透析后，由于浓缩，HRGP和白蛋白水平以相似程度升高，这表明肝素给药后短期内HRGP的周转率未改变。
