Schauer J, Orschekowski H, Steiniger L, Winkler J, Schilling W, Harzbecker K, Evers H
University Hospital, Department of Pulmonology, Leipzig/GDR.
Z Erkr Atmungsorgane. 1990;175(3):132-40.
Calcium antagonists may provide an effective approach to the treatment of pulmonary hypertension disorders. Under this aspect we examined 44 patients by right heart catheterisation at rest and at exercise before and after sublingual application of a single dose of 20 mg nifedipine (Corinfar) as well as under continuous dosage of 30-60 mg daily. In patients with latent pulmonary hypertension we ascertained an efficient significant decrease of PAP, 15 of 18 patients were responders. This protective effect persists in the longterm studies after 1 year as well as after 2 years at equal magnitude. In patients with manifest pulmonary hypertension the influence on pulmonary hemodynamics was not so efficient. This behaviour is caused by morphological fixation of pulmonary hypertension. Therefore the determination of magnitude of pulmonary hypertension by right heart catheterisation is necessary for evaluation of nifedipine therapy.
钙拮抗剂可能为肺动脉高压疾病的治疗提供一种有效方法。在这方面，我们对44例患者进行了研究，在舌下含服单剂量20毫克硝苯地平（可立平）前后以及每日持续服用30 - 60毫克的情况下，于静息和运动状态下通过右心导管检查。在潜在肺动脉高压患者中，我们确定肺动脉压有显著有效降低，18例患者中有15例有反应。这种保护作用在1年以及2年的长期研究中持续存在且程度相同。在显性肺动脉高压患者中，对肺血流动力学的影响效果不佳。这种情况是由肺动脉高压的形态学固定所导致。因此，通过右心导管检查确定肺动脉高压的程度对于评估硝苯地平治疗是必要的。
