Hoyos O Alvaro, Suarez G Margarita, Massaro C Mónica, Ortiz M Gloría, Aguirre C José, Uribe M Andrés
Clínica Universitaria Bolivariana, Medellín, Colombia.
Rev Chilena Infectol. 2010 Dec;27(6):491-8. Epub 2011 Jan 7.
Bloodstream infection (BSI) is one of the main causes of sepsis and death in newborns. The relative importance of nosocomial and non-nosocomial agents in developing countries is not clear. We conducted a prospective study of newborns hospitalized with a first episode of BSI in order to classify it as early, late or nosocomial, describe the clinical and microbiological characteristics, and explore risk factors between hospital-acquired vs community-acquired BSI (HA-BSI vs CA-BSI). Twenty-seven newborns with a first episode of BSI were identified. Streptococcus agalactiae and coagulase negative Staphylococcus were the main agents in CA-BSI and HA-BSI, respectively. The only significant intrinsic risk factor between HA-BSI and CA-BSI was gestational age. The frequent finding of S. agalactiae warrants routine screening and prophylaxis in pregnant women. The risk factors for HA-BSI were mostly extrinsic, and thus, susceptible of being modified.
血流感染（BSI）是新生儿败血症和死亡的主要原因之一。在发展中国家，医院感染性病原体和非医院感染性病原体的相对重要性尚不清楚。我们对首次发生BSI住院的新生儿进行了一项前瞻性研究，以便将其分类为早发型、晚发型或医院获得性，描述其临床和微生物学特征，并探讨医院获得性BSI与社区获得性BSI（HA-BSI与CA-BSI）之间的危险因素。共确定了27例首次发生BSI的新生儿。无乳链球菌和凝固酶阴性葡萄球菌分别是CA-BSI和HA-BSI的主要病原体。HA-BSI和CA-BSI之间唯一显著的内在危险因素是胎龄。无乳链球菌的频繁检出值得对孕妇进行常规筛查和预防。HA-BSI的危险因素大多是外在的，因此易于改变。
