Rotimi V O, Egwari L, Akande B
Department of Medical Microbiology, College of Medicine, University of Lagos, Nigeria.
Afr J Med Med Sci. 1990 Dec;19(4):275-80.
The bactericidal activity of hydrochloric acid (HCl) on different intestinal bacteria was evaluated at various pH values and time intervals. The effect of HCl was highest at pH 2 and pH 3 on strains of Campylobacter jejuni, Aeromonas hydrophila, Plesiomonas shigelloides, Yersinia enterocolitica, Salmonella spp. and Shigella spp., producing complete killing after 60 min incubation. However, at higher pH values (pH 4 and above), these organisms not only survived but they also showed evidence of rapid multiplication. In contrast, clinical and standard strains of Escherichia coli and Staphylococcus aureus were resistant to all the pH values. Highest sensitivity to HCl was observed with strains of Shigella spp. and Salmonella spp. It is conceivable that patients with normal gastric acidity should not suffer from gastroenteritis caused by these intestinal pathogens.
在不同pH值和时间间隔下评估了盐酸（HCl）对不同肠道细菌的杀菌活性。盐酸对空肠弯曲菌、嗜水气单胞菌、类志贺邻单胞菌、小肠结肠炎耶尔森菌、沙门氏菌属和志贺氏菌属菌株的作用在pH 2和pH 3时最强，孵育60分钟后可实现完全杀灭。然而，在较高pH值（pH 4及以上）时，这些微生物不仅存活下来，而且还显示出快速繁殖的迹象。相比之下，大肠杆菌和金黄色葡萄球菌的临床菌株和标准菌株对所有pH值均具有抗性。志贺氏菌属和沙门氏菌属菌株对盐酸的敏感性最高。可以想象，胃酸正常的患者不应患由这些肠道病原体引起的肠胃炎。
