Prevalence of aspirin resistance in stroke patients in Phramongkutklao Hospital.

OBJECTIVE

To study the prevalence of aspirin resistance in cerebrovascular disease patients in Phramongutklao hospital.

MATERIAL AND METHOD

The acute ischemic and stable stroke patients who received aspirin at least 60 mg, at least 7 days and the last dose of aspirin at least 24 hours before blood test for platelet aggregation. ADP and Collagen were used as platelet aggregator.

RESULTS

During July 2007- December 2008, 141 cases of ischemic stroke were enrolled. "Aspirin resistant" was defined as mean aggregation more than 60% both ADP and Collagen. "Aspirin semi-responder" was mean aggregation less than 60% for ADP or Collagen.

CONCLUSION

Prevalence of aspirin resistance in Phramonkutklao hospital is 56 % (79/141), and there are relationship between aspirin resistance and timing in the first episode of stroke.