Department of Veterinary Clinical Medicine, University of Illinois at Urbana Champaign, Urbana, IL, USA.
J Vet Intern Med. 2011 Mar-Apr;25(2):215-21. doi: 10.1111/j.1939-1676.2010.0671.x. Epub 2011 Jan 31.
Plasma citrulline concentration is a reliable marker of global enterocyte mass in humans and is markedly decreased in diffuse small intestinal diseases. However, the relationship between acute intestinal damage and plasma citrulline concentration in dogs has never been documented.
That dogs with parvoviral enteritis have a lower plasma citrulline concentration than healthy dogs and that plasma citrulline concentration is a predictor of death in puppies with parvoviral enteritis.
Sixty-one dogs with spontaneous parvoviral enteritis and 14 healthy age-matched control dogs.
Observational cohort study. Plasma citrulline concentration was measured by liquid chromatography and tandem mass spectrometry in blood samples collected at admission and each day until death or discharge from the hospital. Parvovirus enteritis was confirmed by electron microscopy on a fecal sample.
Median (interquartile range) plasma citrulline concentrations at admission were 2.8 μmol/L (range: 0.3, 49.0; P < .001 versus controls) in survivors (n = 49), 2.1 μmol/L (range: 0.5, 6.4, P < .001 versus controls) in nonsurvivors (n = 12) and 38.6 μmol/L (range: 11.4, 96.1) in controls (n = 14), respectively. There was no significant difference in plasma citrulline concentration between survivors and nonsurvivors within the parvovirus-infected puppies, and plasma citrulline concentration was not significantly associated with outcome in parvoviral enteritis. There were no significant changes in plasma citrulline concentration over the 8-day follow-up period.
Parvovirus enteritis is associated with a severe decrease in plasma citrulline concentration that does not appear to have any significant prognostic value.
血浆瓜氨酸浓度是人类整体肠上皮细胞质量的可靠标志物，在弥漫性小肠疾病中显著降低。然而，犬急性肠损伤与血浆瓜氨酸浓度之间的关系尚未被证实。
感染细小病毒的犬比健康犬的血浆瓜氨酸浓度更低，并且血浆瓜氨酸浓度是感染细小病毒的幼犬死亡的预测指标。
61 只患有自发性细小病毒性肠炎的犬和 14 只年龄匹配的健康对照犬。
观察性队列研究。在入院时和每天直至死亡或出院，通过液相色谱-串联质谱法在血液样本中测量血浆瓜氨酸浓度。通过粪便样本的电子显微镜检查确认细小病毒性肠炎。
存活者（n = 49）入院时的中位（四分位距）血浆瓜氨酸浓度为 2.8 μmol/L（范围：0.3，49.0；P <.001 与对照组相比），非存活者（n = 12）为 2.1 μmol/L（范围：0.5，6.4，P <.001 与对照组相比），对照组（n = 14）为 38.6 μmol/L（范围：11.4，96.1）。在感染细小病毒的幼犬中，存活者和非存活者之间的血浆瓜氨酸浓度无显著差异，并且血浆瓜氨酸浓度与细小病毒性肠炎的结局无显著相关性。在 8 天的随访期间，血浆瓜氨酸浓度没有明显变化。
细小病毒性肠炎与血浆瓜氨酸浓度的严重降低有关，但似乎没有任何显著的预后价值。
