神经传递的基本概念。

Basic concepts of neurotransmission.

作者信息

Patel Dilip R, Feucht Cynthia

机构信息

Department of Pediatrics and Human Development, Michigan State University College of Human Medicine, Kalamazoo, MI 49009-1284, USA.

出版信息

Pediatr Clin North Am. 2011 Feb;58(1):21-31, ix. doi: 10.1016/j.pcl.2010.11.004.

DOI:10.1016/j.pcl.2010.11.004

PMID:21281846

Abstract

An understanding of synaptic neurotransmission is fundamental to the understanding of various neuropsychiatric symptoms and disorders. It is also essential to the discovery of pharmacologic agents that modulate neurotransmission to alleviate such symptoms and conditions. Various aspects of the process of neurotransmission and the synthesis, release, reuptake, or destruction are all potential events for action of therapeutic drugs. This article reviews the basic aspects of relevant neuroanatomy, neurotransmission, and major neurotransmitter systems.

摘要

理解突触神经传递是理解各种神经精神症状和疾病的基础。对于发现调节神经传递以缓解此类症状和病症的药物来说，这也是必不可少的。神经传递过程的各个方面以及神经递质的合成、释放、再摄取或破坏都是治疗药物发挥作用的潜在环节。本文综述了相关神经解剖学、神经传递和主要神经递质系统的基本方面。