螺旋-环-螺旋蛋白在红细胞分化过程中的作用。
Role of helix-loop-helix proteins during differentiation of erythroid cells.
机构信息
Department of Biochemistry and Molecular Biology, College of Medicine, Genetics Institute, Center for Epigenetics, Shands Cancer Center, University of Florida, Gainesville, FL 32610-0245, USA.
出版信息
Mol Cell Biol. 2011 Apr;31(7):1332-43. doi: 10.1128/MCB.01186-10. Epub 2011 Jan 31.
Abstract
Helix-loop-helix (HLH) proteins play a profound role in the process of development and cellular differentiation. Among the HLH proteins expressed in differentiating erythroid cells are the ubiquitous proteins Myc, USF1, USF2, and TFII-I, as well as the hematopoiesis-specific transcription factor Tal1/SCL. All of these HLH proteins exhibit distinct functions during the differentiation of erythroid cells. For example, Myc stimulates the proliferation of erythroid progenitor cells, while the USF proteins and Tal1 regulate genes that specify the differentiated phenotype. This minireview summarizes the known activities of Myc, USF, TFII-I, and Tal11/SCL and discusses how they may function sequentially, cooperatively, or antagonistically in regulating expression programs during the differentiation of erythroid cells.
摘要
螺旋-环-螺旋（HLH）蛋白在发育和细胞分化过程中起着重要作用。在分化的红细胞中表达的 HLH 蛋白中，有普遍存在的蛋白 Myc、USF1、USF2 和 TFII-I，以及造血特异性转录因子 Tal1/SCL。所有这些 HLH 蛋白在红细胞分化过程中都表现出不同的功能。例如，Myc 刺激红细胞祖细胞的增殖，而 USF 蛋白和 Tal1 调节指定分化表型的基因。这篇小综述总结了已知的 Myc、USF、TFII-I 和 Tal11/SCL 的活性，并讨论了它们如何在调节红细胞分化过程中的表达程序时，以顺序、合作或拮抗的方式发挥作用。
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