Pang J F
Post Graduate Medical College of PLA, Beijing.
Zhonghua Kou Qiang Yi Xue Za Zhi. 1990 Sep;25(5):282-4, 318.
For early diagnosis of malignant changes, in oral leukoplakia and lichen planus based upon the experience of experimental study we did before, several non-traumatic examination methods were used in clinical cases. Results showed that the accurate rates of toluidine blue staining and hematoporphyrin derivative (HpD) local application are 90 percent. Transmission electron microscopic study of cytology indicates that cellular ultrastructures are different distinctly between cells of the malignant tissue and normal mucous membrane or leukoplakia with simple hyperplasia.
基于我们之前的实验研究经验，为了早期诊断口腔白斑和扁平苔藓的恶变，我们在临床病例中采用了几种非创伤性检查方法。结果显示，甲苯胺蓝染色和血卟啉衍生物（HpD）局部应用的准确率为90%。细胞学的透射电子显微镜研究表明，恶性组织的细胞与正常黏膜或单纯增生性白斑的细胞之间，细胞超微结构存在明显差异。
