U.O.C. General Surgery, Colorectal Unit, San Martino Hospital, L.go R. Benzi, 10 - 16132 Genoa, Italy.
In Vivo. 2011 Jan-Feb;25(1):129-35.
An evolution of CPH34 (CPH34 HV) for stapled transanal rectal resections was developed and tested to assess its safety and resection volume as compared to other staplers.
A total of 16 pigs were randomly assigned to rectal prolapsectomy with CPH34 HV (n=4), CPH34 (n=4), PPH03-33 (n=4), HEEA (n=2) and PPH-01 (n=2). Measures and histological structure of specimens were assessed; transrectal echotomography (ETG) was performed on the third postoperative day, hence pigs were autopsied.
Significant differences of the volumes and weights of specimens were observed by type of stapler (p=0.0298 and p=0.0278, respectively) which were mainly due to CPH34 HV vs. PPH03-33 (p=0.0402 and p=0.0375, respectively). The average volumes were 17.1% lower for CPH34, 30.2% lower for HEEA, and 34.7% lower for PPH03-33 with respect to CPH34 HV. No significant increase of resection volume (7.5%) was observed between two PPH-01 units combined (two specimens together) vs. a single CPH34 HV unit. The highest percentage of muscularis propria was observed into the specimens collected with CPH34 HV and HEEA (50%). ETG detected three intra- and two extraparietal haematomata.
The safety and higher volume of resection achievable with CPH34 HV correlated well with the specimen weight and percentage of muscularis propria.
为了评估其安全性和切除体积，与其他吻合器相比，对 CPH34（CPH34 HV）进行了改良，用于经肛门直肠切除术吻合。
总共 16 只猪随机分配到直肠脱垂切除术，使用 CPH34 HV（n=4）、CPH34（n=4）、PPH03-33（n=4）、HEEA（n=2）和 PPH-01（n=2）。评估标本的测量和组织学结构；术后第 3 天行经直肠超声（ETG）检查，然后对猪进行剖检。
吻合器类型对标本的体积和重量有显著差异（p=0.0298 和 p=0.0278），主要是 CPH34 HV 与 PPH03-33 之间的差异（p=0.0402 和 p=0.0375）。与 CPH34 HV 相比，CPH34 的平均体积低 17.1%，HEEA 的平均体积低 30.2%，PPH03-33 的平均体积低 34.7%。两个 PPH-01 单位组合（两个标本）与单个 CPH34 HV 单位相比，切除体积没有显著增加（增加 7.5%）。使用 CPH34 HV 和 HEEA 收集的标本中观察到最多的固有肌层（50%）。ETG 检测到三个肌内和两个肌外血肿。
CPH34 HV 的安全性和更高的切除体积与标本重量和固有肌层百分比相关。
