Wazny T K, Mummaw N, Styrt B
Department of Medicine, Michigan State University, East Lansing 48824-1317.
Eur J Clin Microbiol Infect Dis. 1990 Nov;9(11):830-2. doi: 10.1007/BF01967385.
Because an endogenous phospholipase C (PLC) participates in neutrophil activation and because many bacterial pathogens produce PLCs, these studies examined the effect of PLC from Bacillus cereus on the release of the granule enzyme lysozyme from human neutrophils. Bacillus cereus PLC caused dose-dependent lysozyme release, and combined stimulation of neutrophils with PLC and fluoride led to increased secretion. Stimulation of neutrophil degranulation is a potential contributing factor for tissue damage in infections caused by PLC-producing organisms.
由于内源性磷脂酶C（PLC）参与中性粒细胞的激活，且许多细菌病原体可产生PLC，因此这些研究检测了蜡样芽孢杆菌的PLC对人中性粒细胞颗粒酶溶菌酶释放的影响。蜡样芽孢杆菌的PLC引起溶菌酶释放呈剂量依赖性，并且PLC与氟化物联合刺激中性粒细胞可导致分泌增加。刺激中性粒细胞脱颗粒是由产生PLC的生物体引起的感染中组织损伤的一个潜在促成因素。
