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POSSUM 生理学评分在日本择期腹主动脉瘤修复术后发病率和死亡率风险评估中的作用。

Usefulness of POSSUM physiological score for the estimation of morbidity and mortality risk after elective abdominal aortic aneurysm repair in Japan.

机构信息

Division of Vascular Surgery, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.

出版信息

Circ J. 2011;75(3):550-6. doi: 10.1253/circj.cj-09-0576. Epub 2011 Jan 27.

Abstract

BACKGROUND

The Physiological and Operative Severity Score for enUmeration of Mortality and morbidity (POSSUM), which consists of a physiological score (PS) and an operative severity score, is useful in determining the risk profile for patients with abdominal aortic aneurysms in Western countries, but no information is available on the use of this method in Japan.

METHODS AND RESULTS

A retrospective cohort study involving 225 patients was performed, and the prognostic factors for morbidity and in-hospital mortality including POSSUM were investigated. The morbidity rate was 26%. On univariate analysis age, renal disease, hemoglobin, albumin, operation time, blood loss and PS were significantly different. On multivariate analysis PS was significantly different. Using receiver operating characteristic (ROC) analysis, PS had an area under the curve (AUC) of 0.712 and the best cut-off point was 18. The in-hospital mortality rate was 2.2%. On univariate analysis renal disease, albumin and PS were significantly different, and on multivariate analysis PS was significantly different. On ROC analysis PS had an AUC of 0.921 and the best cut-off point was 22.

CONCLUSIONS

PS was the only independent risk factor for morbidity and in-hospital mortality. Further studies may be required to develop a risk-scoring system.

摘要

背景

生理和手术严重程度评分用于病死率和发病率的评估(POSSUM),包括生理评分(PS)和手术严重程度评分,在确定西方国家腹主动脉瘤患者的风险状况方面很有用,但在日本使用这种方法的信息尚不清楚。

方法和结果

对 225 例患者进行了回顾性队列研究,并对包括 POSSUM 在内的发病率和住院死亡率的预后因素进行了研究。发病率为 26%。单因素分析显示,年龄、肾脏疾病、血红蛋白、白蛋白、手术时间、出血量和 PS 有显著差异。多因素分析显示 PS 有显著差异。使用受试者工作特征(ROC)分析,PS 的曲线下面积(AUC)为 0.712,最佳截断点为 18。住院死亡率为 2.2%。单因素分析显示肾脏疾病、白蛋白和 PS 有显著差异,多因素分析显示 PS 有显著差异。ROC 分析显示 PS 的 AUC 为 0.921,最佳截断点为 22。

结论

PS 是发病率和住院死亡率的唯一独立危险因素。可能需要进一步研究来开发风险评分系统。

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