Weidauer T, Timmermann J
Radiologische Abteilung, Marienhospital in Altenessen, Akademisches Lehrkrankenhaus der Gesamthochschule Essen.
Fortschr Med. 1990 Dec 20;108(36):700-2.
In this study, 12 patients with arterial occlusions of the lower limb were treated with low-dose intra-arterial rt-PA. Although the group was heterogeneous (differences in length and duration of occlusion), good short-term and medium-term results were obtained. After local treatment with 2.5 mg/h rt-PA administered intra-arterially over 2.5 to 8 hours, most patients had no, or only mild, residual stenosis. Posttherapy, almost all patients were able to walk longer distances. Side effects were rare, and in only one case did treatment have to be discontinued because of pain in the treated limb.
在本研究中，12例下肢动脉闭塞患者接受了低剂量动脉内rt-PA治疗。尽管该组患者情况各异（闭塞长度和持续时间不同），但仍取得了良好的短期和中期效果。在以2.5毫克/小时的速率动脉内给予rt-PA进行2.5至8小时的局部治疗后，大多数患者没有或仅有轻度残余狭窄。治疗后，几乎所有患者都能行走更长的距离。副作用很少见，仅1例因治疗肢体疼痛而不得不停止治疗。
