台湾地区基于人群的隐球菌性脑膜炎的全国性流行病学研究。

Nationwide population-based epidemiologic study of cryptococcal meningitis in Taiwan.

机构信息

Department of Neurology, Changhua Christian Hospital, Changhua, Taiwan, ROC.

出版信息

Neuroepidemiology. 2011;36(2):79-84. doi: 10.1159/000323390. Epub 2011 Feb 1.

DOI:10.1159/000323390

PMID:21282964

Abstract

BACKGROUND

Little is known about the epidemiology of cryptococcal meningitis in Taiwan. The aim of this study was to conduct the first nationwide population-based epidemiologic study of cryptococcal meningitis in Taiwan.

METHODS

Cases of cryptococcal meningitis were identified from the annual hospitalization discharge claims of the National Health Insurance Research Database with the corresponding ICD-9 code 321.0 from January 2000 to December 2007.

RESULTS

A total of 845 incident cases of cryptococcal meningitis were detected. Among them, 109 patients (12.9%) had human immunodeficiency virus (HIV) infection. The average incidence was 4.7 per million person-years. The incidence remarkably increased in the age group of 60-69 years, peaked in the age group of 70-79 years, and fell after the age of 80 years. The average incidence for men was 2.2-fold higher than that for women. The most common complication was obstructive hydrocephalus in 15.3% of the patients, followed by acute respiratory failure in 12.0% of the patients.

CONCLUSION

This is the first population-based epidemiologic study of cryptococcal meningitis in Taiwan. The incidence was stable during the study period, and most cases were non-HIV related.

摘要

背景

关于台湾地区隐球菌性脑膜炎的流行病学情况，目前所知甚少。本研究旨在开展台湾地区首例基于人群的隐球菌性脑膜炎的流行病学研究。

方法

从 2000 年 1 月至 2007 年 12 月，我们通过国家健康保险研究数据库中年度住院出院记录的相应 ICD-9 编码 321.0 ，确定了隐球菌性脑膜炎的病例。

结果

共发现 845 例隐球菌性脑膜炎的发病病例。其中 109 例（12.9%）患者有人免疫缺陷病毒（HIV）感染。平均发病率为每百万人每年 4.7 例。发病率在 60-69 岁年龄组显著增加，在 70-79 岁年龄组达到峰值，80 岁后下降。男性的平均发病率是女性的 2.2 倍。最常见的并发症是梗阻性脑积水（15.3%的患者），其次是急性呼吸衰竭（12.0%的患者）。