The inv(3)(q21q26)/t(3;3)(q21;q26) is frequently accompanied by alterations of the RUNX1, KRAS and NRAS and NF1 genes and mediates adverse prognosis both in MDS and in AML: a study in 39 cases of MDS or AML.

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作者信息

Haferlach C, Bacher U, Haferlach T, Dicker F, Alpermann T, Kern W, Schnittger S

出版信息

Leukemia. 2011 May;25(5):874-7. doi: 10.1038/leu.2011.5. Epub 2011 Feb 1.

DOI:10.1038/leu.2011.5

PMID:21283084

Abstract

摘要

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The inv(3)(q21q26)/t(3;3)(q21;q26) is frequently accompanied by alterations of the RUNX1, KRAS and NRAS and NF1 genes and mediates adverse prognosis both in MDS and in AML: a study in 39 cases of MDS or AML.

Leukemia. 2011 May;25(5):874-7. doi: 10.1038/leu.2011.5. Epub 2011 Feb 1.

Myelodysplastic syndrome with inv(3)(q21q26.2) or t(3;3)(q21;q26.2) has a high risk for progression to acute myeloid leukemia.骨髓增生异常综合征伴 inv(3)(q21q26.2) 或 t(3;3)(q21;q26.2) 易向急性髓系白血病转化，风险较高。

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[Myelodysplastic syndromes and acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2) abnormality].伴有inv(3)(q21q26.2)或t(3;3)(q21;q26.2)异常的骨髓增生异常综合征和急性髓系白血病

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