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The inv(3)(q21q26)/t(3;3)(q21;q26) is frequently accompanied by alterations of the RUNX1, KRAS and NRAS and NF1 genes and mediates adverse prognosis both in MDS and in AML: a study in 39 cases of MDS or AML.

作者信息

Haferlach C, Bacher U, Haferlach T, Dicker F, Alpermann T, Kern W, Schnittger S

出版信息

Leukemia. 2011 May;25(5):874-7. doi: 10.1038/leu.2011.5. Epub 2011 Feb 1.

DOI:10.1038/leu.2011.5
PMID:21283084
Abstract
摘要

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1
The inv(3)(q21q26)/t(3;3)(q21;q26) is frequently accompanied by alterations of the RUNX1, KRAS and NRAS and NF1 genes and mediates adverse prognosis both in MDS and in AML: a study in 39 cases of MDS or AML.
Leukemia. 2011 May;25(5):874-7. doi: 10.1038/leu.2011.5. Epub 2011 Feb 1.
2
Myelodysplastic syndrome with inv(3)(q21q26.2) or t(3;3)(q21;q26.2) has a high risk for progression to acute myeloid leukemia.骨髓增生异常综合征伴 inv(3)(q21q26.2) 或 t(3;3)(q21;q26.2) 易向急性髓系白血病转化，风险较高。
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Three novel cytogenetically cryptic EVI1 rearrangements associated with increased EVI1 expression and poor prognosis identified in 27 acute myeloid leukemia cases.在 27 例急性髓系白血病病例中发现了三种新型细胞遗传学隐匿性 EVI1 重排，这些重排与 EVI1 表达增加和预后不良相关。
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Development of a dual-color, double fusion FISH assay to detect RPN1/EVI1 gene fusion associated with inv(3), t(3;3), and ins(3;3) in patients with myelodysplasia and acute myeloid leukemia.开发一种双色、双重融合 FISH 检测方法，以检测骨髓增生异常和急性髓系白血病患者中与 inv(3)、t(3;3)和 ins(3;3)相关的 RPN1/EVI1 基因融合。
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The New Clinicopathologic and Molecular Findings in Myeloid Neoplasms With inv(3)(q21q26)/t(3;3)(q21;q26.2).伴有inv(3)(q21q26)/t(3;3)(q21;q26.2)的髓系肿瘤的新临床病理及分子学发现
Arch Pathol Lab Med. 2016 Dec;140(12):1404-1410. doi: 10.5858/arpa.2016-0059-RA. Epub 2016 Sep 15.
6
Complex or monosomal karyotype and not blast percentage is associated with poor survival in acute myeloid leukemia and myelodysplastic syndrome patients with inv(3)(q21q26.2)/t(3;3)(q21;q26.2): a Bone Marrow Pathology Group study.复杂或单体核型而非原始细胞百分比与急性髓系白血病和伴有inv(3)(q21q26.2)/t(3;3)(q21;q26.2)的骨髓增生异常综合征患者的不良生存相关：一项骨髓病理学组研究。
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7
[Myelodysplastic syndromes and acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2) abnormality].伴有inv(3)(q21q26.2)或t(3;3)(q21;q26.2)异常的骨髓增生异常综合征和急性髓系白血病
Med Clin (Barc). 2015 Sep 7;145(5):224-6. doi: 10.1016/j.medcli.2014.07.001. Epub 2014 Sep 2.
8
Clinical, molecular, and prognostic significance of WHO type inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and various other 3q abnormalities in acute myeloid leukemia.急性髓系白血病中 WHO 类型 inv(3)(q21q26.2)/t(3;3)(q21;q26.2) 和其他各种 3q 异常的临床、分子和预后意义。
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Myelodysplastic syndrome/acute myeloid leukemia with t(3;21)(q26.2;q22) is commonly a therapy-related disease associated with poor outcome.骨髓增生异常综合征/伴有 t(3;21)(q26.2;q22) 的急性髓系白血病通常是一种与不良预后相关的治疗相关疾病。
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A case of atypical myelodysplastic syndrome with micromegakaryocytes, normal platelet count, and t(3;12)(q21;p13) with inv(3)(q21q26).1例伴有微巨核细胞、血小板计数正常且存在t(3;12)(q21;p13)及inv(3)(q21q26)的非典型骨髓增生异常综合征。
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Blood. 2022 Jan 20;139(3):323-332. doi: 10.1182/blood.2021011304.
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