Can Fam Physician. 1983 Feb;29:285-8.
Verapamil, nifedipine, and diltiazem are drugs which decrease intracellular calcium in cardiac muscle, smooth muscle, and nodal cardiac cells. Unlike B-blockers, each drug acts at a different site on the cell membrane and has an important difference in overall action. Verapamil is used to treat angina, systemic hypertension, hypertrophic cardiomyopathy, and supraventricular and junctional tachyarrhythmias. Nifedipine is useful in angina, vasospastic disorders, and hypertension. A specific role for diltiazem is now being defined.
维拉帕米、硝苯地平、地尔硫卓是降低心肌、平滑肌和心脏结细胞细胞内钙的药物。与β受体阻滞剂不同，每种药物在细胞膜的不同部位起作用，其总体作用有重要差异。维拉帕米用于治疗心绞痛、全身性高血压、肥厚型心肌病和室上性及结性心动过速。硝苯地平对心绞痛、血管痉挛性疾病和高血压有效。地尔硫卓的具体作用正在确定中。
