Latulippe L
Can Fam Physician. 1983 Feb;29:296-9.
Raynaud's phenomenon can be idiopathic (Raynaud's disease) and is found in healthy individuals or secondary to various conditions. Our perception of Raynaud's phenomenon has made a clear progression, partly due to a more useful set of diagnostic criteria for those rheumatic inflammatory diseases which are autoimmune. When it is unilateral, a vascular cause is generally found. When it is bilateral, there is usually an association with a systemic disorder. Laboratory investigation should be undertaken only if the physical findings suggest it. The etiology of Raynaud's disease remains unknown. Medications proposed for its treatment are aimed at suppressing adrenergic neuronal activity of the sympathetic nervous system (reserpine, guanethidine, methyldopa) or suppressing alpha receptor activity (phenoxybenzamine, prazosin) or stimulating beta receptor activity (isoxsuprine, terbutaline).
雷诺现象可原发性(雷诺病),见于健康个体,或继发于各种疾病。我们对雷诺现象的认识有了明显进展,部分原因是针对自身免疫性风湿性炎症性疾病有了一套更有用的诊断标准。当雷诺现象为单侧时,通常可发现血管性病因。当为双侧时,通常与全身性疾病有关。仅当体格检查结果提示时才应进行实验室检查。雷诺病的病因仍不明。用于治疗的药物旨在抑制交感神经系统的肾上腺素能神经元活性(利血平、胍乙啶、甲基多巴)或抑制α受体活性(酚苄明、哌唑嗪)或刺激β受体活性(异克舒令、特布他林)。