通过驯服移植内不良固有免疫来创造移植耐受。
Creating transplant tolerance by taming adverse intragraft innate immunity.
作者信息
Hanidziar Dusan, Koulmanda Maria, Strom Terry B
机构信息
Departments of Medicine and Surgery, Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, E/CLS 608 Boston, MA 02215 USA.
出版信息
F1000 Biol Rep. 2010 Nov 24;2:83. doi: 10.3410/B2-83.
Certain forms of inflammation of an allograft are highly detrimental to the induction and maintenance of transplant tolerance as they foster stable commitment to graft-destructive, not graft-protective, forms of T-cell immunity. Hence, a reduction in adverse tissue inflammation may prove crucial in facilitating the induction and maintenance of a long-lasting state of transplant tolerance.
同种异体移植物的某些炎症形式对移植耐受的诱导和维持极为不利，因为它们促进了对移植物具有破坏性而非保护性的T细胞免疫形式的稳定发展。因此，减少不良组织炎症可能对促进持久移植耐受状态的诱导和维持至关重要。
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