Laboratory of Genetics and Molecular Cardiology, Medical School, Heart Institute, University of São Paulo, São Paulo, Brazil.
PLoS One. 2011 Jan 20;6(1):e16341. doi: 10.1371/journal.pone.0016341.
To determine whether information from genetic risk variants for diabetes is associated with cardiovascular events incidence.
From the about 30 known genes associated with diabetes, we genotyped single-nucleotide polymorphisms at the 10 loci most associated with type-2 diabetes in 425 subjects from the MASS-II Study, a randomized study in patients with multi-vessel coronary artery disease. The combined genetic information was evaluated by number of risk alleles for diabetes. Performance of genetic models relative to major cardiovascular events incidence was analyzed through Kaplan-Meier curve comparison and Cox Hazard Models and the discriminatory ability of models was assessed for cardiovascular events by calculating the area under the ROC curve.
Genetic information was able to predict 5-year incidence of major cardiovascular events and overall-mortality in non-diabetic individuals, even after adjustment for potential confounders including fasting glycemia. Non-diabetic individuals with high genetic risk had a similar incidence of events then diabetic individuals (cumulative hazard of 33.0 versus 35.1% of diabetic subjects). The addition of combined genetic information to clinical predictors significantly improved the AUC for cardiovascular events incidence (AUC = 0.641 versus 0.610).
Combined information of genetic variants for diabetes risk is associated to major cardiovascular events incidence, including overall mortality, in non-diabetic individuals with coronary artery disease.
Medicine, Angioplasty, or Surgery Study (MASS II). Unique identifier: ISRCTN66068876 URL.
确定糖尿病遗传风险变异体信息是否与心血管事件的发生有关。
在与 2 型糖尿病相关的约 30 个已知基因中，我们对与 2 型糖尿病关联最密切的 10 个基因座中的单核苷酸多态性在来自 MASS-II 研究的 425 名多血管冠状动脉疾病患者中进行了基因分型。通过糖尿病风险等位基因的数量来评估联合遗传信息。通过 Kaplan-Meier 曲线比较和 Cox 风险模型分析遗传模型相对于主要心血管事件发生率的性能，并通过计算 ROC 曲线下面积来评估模型对心血管事件的判别能力。
遗传信息能够预测非糖尿病个体 5 年内主要心血管事件和总死亡率的发生，即使在调整了包括空腹血糖在内的潜在混杂因素后也是如此。具有高遗传风险的非糖尿病个体的事件发生率与糖尿病个体相似（累积风险为 33.0%与糖尿病患者的 35.1%）。将联合遗传信息添加到临床预测因子中，显著提高了心血管事件发生率的 AUC（AUC=0.641 与 0.610）。
糖尿病风险的遗传变异联合信息与非糖尿病冠心病患者的主要心血管事件发生，包括总死亡率有关。
Medicine, Angioplasty, or Surgery Study (MASS II)。唯一标识符：ISRCTN66068876 URL。
Zotero 插件
