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硫酸亚铁:一种常用药物的急性中毒

[Ferrous sulfate: acute poisoning with a frequent use drug].

作者信息

Mariano Díaz, Cabrerizo Silvia, Docampo Patricia C

机构信息

Centro Nacional de Intoxicaciones, Hospital Nacional Profesor Alejandro Posadas, Argentina.

出版信息

Arch Argent Pediatr. 2011 Feb;109(1):1-3. doi: 10.1590/S0325-00752011000100015.

Abstract

The iron is the main component of hemoglobin and is also part of myoglobin and enzymes. Its deficit is the most common cause of nutritional anemia in humans. The use of iron salts is very common in children, because they are indicated for prophylaxis and treatment of iron deficiency anemia. The availability in households and the emergence of flavored formulations that promote adherence to treatment, greatly assist in this type of poisoning. Usually, the overdose is considered a low hazard, because it is a mineral supplement added in many of the baby food. Iron in free state is able of producing toxicity, disrupting multiple cellular processes by catalyzing redox reactions with lipid peroxidation and free radical formation. We report a case of serious toxicity by iron salts, in which early intervention and management with specific chelator, allowed a favorable evolution.

摘要

铁是血红蛋白的主要成分,也是肌红蛋白和酶的组成部分。铁缺乏是人类营养性贫血最常见的原因。铁盐在儿童中使用非常普遍,因为它们适用于缺铁性贫血的预防和治疗。家庭中容易获取以及出现了促进治疗依从性的调味制剂,极大地助长了这类中毒事件的发生。通常,过量摄入被认为危害较小,因为它是许多婴儿食品中添加的一种矿物质补充剂。游离状态的铁能够产生毒性,通过催化脂质过氧化和自由基形成的氧化还原反应扰乱多个细胞过程。我们报告一例铁盐严重中毒病例,其中通过使用特定螯合剂进行早期干预和处理,实现了良好的病情转归。

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