Manuilova I A, Nazarenko T A, Mullabaeva S M
Probl Endokrinol (Mosk). 1990 Nov-Dec;36(6):40-4.
Differentiated clinico-hormonal investigation using diagnostic LH-RH testing made it possible to reveal various conditions of patients with hypogonadotropic amenorrhea. The expression of clinical signs of hypoestrogenemia corresponded to a degree of hormonal insufficiency. The investigation permitted the evaluation of the prospects of perganol-stimulated ovulation and a choice of an optimum initial drug dose. Patients with moderate estrogenic insufficiency responding positively to LH-RH, were shown promising for perganol therapy. Pregnancy was noted in 86.4%, the initial drug dose was 2-3 ampules per day. In negative LH-RH testing pregnancy was noted in 12% of the patients only. The stimulation of ovulation in such patients should be started with a daily dose of 4-5 ampules of pergonal.
采用诊断性促黄体生成素释放激素（LH-RH）检测进行的差异化临床激素检查，使得揭示低促性腺激素性闭经患者的各种情况成为可能。低雌激素血症临床症状的表现与激素不足程度相对应。该检查有助于评估人绝经期促性腺激素（Perganol）刺激排卵的前景，并选择最佳初始药物剂量。对LH-RH反应呈阳性的中度雌激素不足患者，显示出接受Perganol治疗的良好前景。86.4%的患者成功妊娠，初始药物剂量为每日2 - 3安瓿。在LH-RH检测呈阴性的患者中，仅12%的患者成功妊娠。此类患者的排卵刺激应以每日4 - 5安瓿的Pergonal剂量开始。
