Department of Otolaryngology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan, Republic of China.
Head Neck. 2011 Dec;33(12):1703-7. doi: 10.1002/hed.21662. Epub 2011 Jan 31.
The purpose of this study was to present the impact of clinicopathological factors on patient survival in tonsillar squamous cell carcinoma (SCC) that needs to be evaluated.
This study enrolled 86 patients with tonsillar SCC undergoing surgical resection.
The cumulative 5-year disease-specific survival (DSS) rate for stages I, II, III, and IVa/b tumors was 100%, 91.7%, 100%, and 61.8%, respectively. Unfavorable cumulative 5-year DSS rates were significantly correlated with advanced T classification (p = .029), tumor thickness over 1 cm (p = .007), 3 or more positive neck lymph nodes (p < .001), and extracapsular spread (ECS; p = .002). Cox regression analysis revealed that the presence of 3 or more positive neck lymph nodes (p = .035) and the stage IVa/b (p = .022) were the independent predictors of the 5-year DSS.
Patients with tonsillar SCC with stage IVa/b and metastasis to 3 or more lymph nodes have poorer clinical outcomes. Novel therapeutic strategies are necessary for these patients.
本研究旨在探讨临床病理因素对需要评估的扁桃体鳞状细胞癌（SCC）患者生存的影响。
本研究纳入 86 例接受扁桃体 SCC 切除术的患者。
Ⅰ、Ⅱ、Ⅲ和Ⅳa/b 期肿瘤的 5 年疾病特异性生存率（DSS）分别为 100%、91.7%、100%和 61.8%。累积 5 年 DSS 率较差与晚期 T 分类（p =.029）、肿瘤厚度超过 1cm（p =.007）、3 个或更多阳性颈部淋巴结（p <.001）和囊外扩散（ECS；p =.002）显著相关。Cox 回归分析显示，3 个或更多阳性颈部淋巴结（p =.035）和Ⅳa/b 期（p =.022）是 5 年 DSS 的独立预测因素。
扁桃体 SCC 伴Ⅳa/b 期和转移至 3 个或更多淋巴结的患者临床结局较差。这些患者需要新的治疗策略。
