TF1，一种噬菌体特异性DNA结合和DNA弯曲蛋白。

TF1, a bacteriophage-specific DNA-binding and DNA-bending protein.

作者信息

Geiduschek E P, Schneider G J, Sayre M H

机构信息

Department of Biology, University of California, San Diego, La Jolla 92093.

出版信息

J Struct Biol. 1990 Jul-Sep;104(1-3):84-90. doi: 10.1016/1047-8477(90)90061-g.

DOI:10.1016/1047-8477(90)90061-g

PMID:2128458

Abstract

We review and discuss the biological and DNA-binding properties of the bacteriophage SPO1 transcription factor 1 (TF1), a DNA-binding protein belonging to the ubiquitous prokaryotic family of Type II DNA-binding proteins. We review recent information on the effects of certain mutations in TF1 on DNA-binding and on its ability to sharply bend DNA. We also compare the DNA-binding properties of the three best-studied type II DNA-binding proteins, Escherichia coli HU, E. coli integration host factor, and TF1, and discuss them in the context of the structure and properties of chromatin in prokaryotes.

摘要

我们回顾并讨论了噬菌体SPO1转录因子1（TF1）的生物学和DNA结合特性，TF1是一种属于普遍存在的II型DNA结合蛋白原核家族的DNA结合蛋白。我们回顾了有关TF1中某些突变对DNA结合及其使DNA急剧弯曲能力的影响的最新信息。我们还比较了三种研究得最透彻的II型DNA结合蛋白，即大肠杆菌HU、大肠杆菌整合宿主因子和TF1的DNA结合特性，并在原核生物染色质的结构和特性背景下对它们进行了讨论。