PARP-1: a new player in the asthma field?
作者信息
Szabó É, Kovács I, Grune T, Haczku A, Virág L
出版信息
Allergy. 2011 Jul;66(7):811-4. doi: 10.1111/j.1398-9995.2011.02551.x. Epub 2011 Feb 2.
Abstract
摘要
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PARP-1: a new player in the asthma field?聚（ADP-核糖）聚合酶-1：哮喘领域的新角色？
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Collaborator of Stat6 (CoaSt6)-associated poly(ADP-ribose) polymerase activity modulates Stat6-dependent gene transcription.与Stat6相关的多聚（ADP-核糖）聚合酶活性的合作者（CoaSt6）调节Stat6依赖性基因转录。
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Beyond DNA repair, the immunological role of PARP-1 and its siblings.除了 DNA 修复，PARP-1 及其同源物的免疫学作用。
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本文引用的文献
1
PARP-1 deficiency blocks IL-5 expression through calpain-dependent degradation of STAT-6 in a murine asthma model.PARP-1 缺陷通过钙蛋白酶依赖性降解 STAT-6 阻断哮喘模型中 IL-5 的表达。
Allergy. 2011 Jul;66(7):853-61. doi: 10.1111/j.1398-9995.2011.02549.x. Epub 2011 Jan 28.
2
Increased poly(ADP-ribose) polymerase (PARP)-1 expression and activity are associated with inflammation but not goblet cell metaplasia in murine models of allergen-induced airway inflammation.在变应原诱导的气道炎症小鼠模型中，聚（ADP - 核糖）聚合酶（PARP）-1表达和活性增加与炎症相关，但与杯状细胞化生无关。
Exp Lung Res. 2010 Sep;36(7):381-9. doi: 10.3109/01902141003663360.
3
Chromatin repair after oxidative stress: role of PARP-mediated proteasome activation.氧化应激后的染色质修复：PARP 介导的蛋白酶体激活的作用。
Free Radic Biol Med. 2010 Mar 1;48(5):673-80. doi: 10.1016/j.freeradbiomed.2009.12.010. Epub 2009 Dec 16.
4
The proteasomal system.蛋白酶体系统
Mol Aspects Med. 2009 Aug;30(4):191-296. doi: 10.1016/j.mam.2009.04.001. Epub 2009 Apr 14.
5
The cytokine network in asthma and chronic obstructive pulmonary disease.哮喘和慢性阻塞性肺疾病中的细胞因子网络
J Clin Invest. 2008 Nov;118(11):3546-56. doi: 10.1172/JCI36130.
6
PARP-1 modulates deferoxamine-induced HIF-1alpha accumulation through the regulation of nitric oxide and oxidative stress.聚（ADP-核糖）聚合酶-1通过调节一氧化氮和氧化应激来调控去铁胺诱导的低氧诱导因子-1α蓄积。
J Cell Biochem. 2008 Aug 15;104(6):2248-60. doi: 10.1002/jcb.21781.
7
Regulation of transcription factor NFAT by ADP-ribosylation.ADP核糖基化对转录因子NFAT的调控
Mol Cell Biol. 2008 May;28(9):2860-71. doi: 10.1128/MCB.01746-07. Epub 2008 Feb 25.
8
Post-allergen challenge inhibition of poly(ADP-ribose) polymerase harbors therapeutic potential for treatment of allergic airway inflammation.变应原激发后抑制聚（ADP - 核糖）聚合酶具有治疗过敏性气道炎症的潜力。
Clin Exp Allergy. 2008 May;38(5):839-46. doi: 10.1111/j.1365-2222.2008.02943.x. Epub 2008 Feb 4.
9
Regulation of NFAT by poly(ADP-ribose) polymerase activity in T cells.T细胞中聚（ADP-核糖）聚合酶活性对NFAT的调节作用。
Mol Immunol. 2008 Apr;45(7):1863-71. doi: 10.1016/j.molimm.2007.10.044.
10
The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases.哺乳动物PARP的多种生物学作用，PARP是一个虽小但功能强大的聚ADP核糖聚合酶家族。
Front Biosci. 2008 Jan 1;13:3046-82. doi: 10.2741/2909.
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