AMPK 依赖性磷酸化 ULK1 诱导自噬。
AMPK-dependent phosphorylation of ULK1 induces autophagy.
机构信息
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
Cell Metab. 2011 Feb 2;13(2):119-20. doi: 10.1016/j.cmet.2011.01.009.
Abstract
AMP-activated protein kinase (AMPK) is a highly conserved cellular energy sensor that plays a central role in metabolic homeostasis. A recent study in Science (Egan et al., 2011) identifies ULK1 as a substrate for AMPK phosphorylation, a modification required for selective autophagy of mitochondria and cell survival during starvation.
摘要
腺苷酸活化蛋白激酶（AMPK）是一种高度保守的细胞能量感受器，在代谢稳态中起着核心作用。最近发表在《科学》杂志上的一项研究（Egan 等人，2011 年）确定 ULK1 是 AMPK 磷酸化的底物，这种修饰对于饥饿时线粒体的选择性自噬和细胞存活是必需的。
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