多巴胺能突触处的单胺氧化酶与氧化应激
Monoamine oxidase and oxidative stress at dopaminergic synapses.
作者信息
Cohen G
机构信息
Department of Neurology, Mount Sinai School of Medicine, New York.
出版信息
J Neural Transm Suppl. 1990;32:229-38. doi: 10.1007/978-3-7091-9113-2_33.
PMID:2128499
Abstract
Increased oxidation of dopamine by monoamine oxidase (MAO) in the striatum is associated with an oxidant stress, expressed as a rise in the level of oxidized glutathione. Oxidation of glutathione is suppressed by MAO inhibitors, such as deprenyl and clorgyline. These observations related to Parkinson's disease and to the clinical trial of deprenyl as an agent that may retard progression of the disease.
摘要
纹状体中多巴胺被单胺氧化酶（MAO）氧化增加与氧化应激相关，表现为氧化型谷胱甘肽水平升高。谷胱甘肽的氧化受到MAO抑制剂（如司来吉兰和氯吉兰）的抑制。这些观察结果与帕金森病以及司来吉兰作为一种可能延缓疾病进展药物的临床试验有关。
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