大鼠脑和肝脏中的慢性乙醇喂养与二胺氧化酶活性
Chronic ethanol feeding and diamine oxidase activity in rat brain and liver.
作者信息
Sessa A, Perin A
机构信息
Centro di Studio sulla Patologia Cellulare, C.N.R., Milan, Italy.
出版信息
J Neural Transm Suppl. 1990;32:319-22. doi: 10.1007/978-3-7091-9113-2_41.
PMID:2128502
Abstract
The activity of diamine oxidase, the principal enzyme for diamine catabolism, was evaluated in brain and liver from male rats fed nutritionally complete diets, of which 36% of total calories was given as ethanol or as isocaloric carbohydrates for 4 months. Ethanol caused an increase in diamine oxidase activity in the brain and a decrease in the liver, tissues with a low and high rate of ethanol oxidation, respectively.
摘要
在以营养成分齐全的日粮喂养的雄性大鼠中，评估了二胺氧化酶（二胺分解代谢的主要酶）的活性。这些大鼠的日粮中，总热量的36%分别以乙醇或等热量碳水化合物的形式提供，持续4个月。乙醇导致大脑中二胺氧化酶活性增加，而肝脏中该酶活性降低，大脑和肝脏分别是乙醇氧化速率低和高的组织。
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