乙醇与豚鼠肝脏中腐胺和组胺氧化的关系。
Ethanol involvement in putrescine and histamine oxidation by guinea pig liver.
作者信息
Biegański T, Fogel W A, Korsak Z, Maśliński C, Osińska Z, Ulatowska M A
出版信息
Pol J Pharmacol Pharm. 1984 Nov-Dec;36(6):633-40.
The in vitro influence of ethanol and acetaldehyde on diamine oxidase catalyzed reaction was measured with guinea pig liver and intestine. Acetaldehyde, having no influence on diamine oxidase activity, diminished the formation of gamma-aminobutyric acid or imidazole-4-acetic acid when putrescine or histamine were used, respectively, as enzyme substrate. During ethanol ingestion by guinea pig the enhancement of hepatic diamine oxidase activity was observed after 10 days of treatment with subsequent decrease to the control value on the 18th day. The metabolic products of putrescine in diamine oxidase catalyzed reaction by livers of alcohol animals show similar increase and the same time course as enzymic activity. The per cent distribution of particular products in diamine oxidase reaction was not affected by ethanol administration.
用豚鼠肝脏和肠道测定了乙醇和乙醛对二胺氧化酶催化反应的体外影响。乙醛对二胺氧化酶活性没有影响，但当分别使用腐胺或组胺作为酶底物时，会减少γ-氨基丁酸或咪唑-4-乙酸的形成。豚鼠摄入乙醇后，在治疗10天后观察到肝脏二胺氧化酶活性增强，随后在第18天降至对照值。酒精处理动物肝脏中二胺氧化酶催化反应中腐胺的代谢产物显示出与酶活性相似的增加和相同的时间进程。二胺氧化酶反应中特定产物的百分比分布不受乙醇给药的影响。
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