通过大冰冻切片放射自显影术对阿尔茨海默病型痴呆患者脑单胺氧化酶B（MAO-B）的可视化：一项初步研究。

Visualization of brain monoamine oxidase B (MAO-B) in dementia of Alzheimer's type by means of large cryosection autoradiography: a pilot study.

作者信息

Jossan S S, Gillberg P G, Karlsson I, Gottfries C G, Oreland L

机构信息

Department of Medical Pharmacology, University of Uppsala, Sweden.

出版信息

J Neural Transm Suppl. 1990;32:61-5. doi: 10.1007/978-3-7091-9113-2_7.

DOI:10.1007/978-3-7091-9113-2_7

PMID:2128513

Abstract

Quantitative autoradiography, using 3H-deprenyl, was applied to study the regional localization of MAO-B in large cryosections from 3 control brains and 3 brains from patients with Alzheimer's disease (AD). High 3H-L-deprenyl binding was found in e.g. basal ganglia, cingulate gyrus, and insula cortex. Temporal cortex, parietal cortex, occipital cortex and various nuclei of the thalamus, showed moderate density, while low binding was observed in e.g. white matter. When the brains from the controls were compared with those with AD, the mean values for 3H-deprenyl binding was higher in the latter group, however, more generalised than previously reported.

摘要

运用³H-司来吉兰进行定量放射自显影，以研究3个对照大脑和3个阿尔茨海默病（AD）患者大脑的大冰冻切片中MAO-B的区域定位。例如，在基底神经节、扣带回和岛叶皮质中发现了高³H-L-司来吉兰结合。颞叶皮质、顶叶皮质、枕叶皮质以及丘脑的各个核团显示出中等密度，而例如白质中则观察到低结合。当将对照组的大脑与AD患者的大脑进行比较时，后一组中³H-司来吉兰结合的平均值更高，然而，比先前报道的更为普遍。