Department of Pathology, University of Veterinary Medicine Hannover, Bünteweg 17, D-30559 Hannover, Germany.
Vet Pathol. 2011 Jul;48(4):906-10. doi: 10.1177/0300985810381243. Epub 2011 Feb 1.
Incisional biopsies from the oral cavity of 2 adult cats were submitted for histological investigation. Cat No. 1 showed a solitary well-circumscribed neoplasm in the left mandible. Cat No. 2 demonstrated a diffusely infiltrating neoplasm in the left maxilla. Both tumors consisted of medium-size epithelial cells embedded in a fibrovascular stroma. The mitotic index was 0 to 1 mitosis per high-power field. The epithelial cells showed an irregular arrangement forming nests or streams in cat No. 1, whereas a palisading growth was noted in cat No. 2. Both tumors, especially that of cat No. 1, showed multifocal accumulations of amyloid as confirmed by Congo red staining and a distinct green birefringence under polarized light, which lacked cytokeratin immunoreactivity as well as and AL and AA amyloid immunoreactivity. In addition, the amyloid in cat No. 2 was positive for the odontogenic ameloblast-associated protein, formerly termed APin. In sum, both cats suffered from an amyloid-producing odontogenic tumor, but their tumors varied with respect to morphology and type of amyloid produced.
两份来自成年猫口腔的切开活检组织被提交用于组织学研究。病例 1 的左侧下颌骨有一个孤立的、边界清楚的肿瘤。病例 2 的左侧上颌骨有一个弥漫浸润性肿瘤。两个肿瘤均由中等大小的上皮细胞嵌入纤维血管基质组成。有丝分裂指数为每高倍视野 0-1 个有丝分裂。上皮细胞在病例 1 中排列不规则，形成巢状或流状，而在病例 2 中则呈现出栅栏状生长。两个肿瘤，尤其是病例 1 的肿瘤，刚果红染色证实有局灶性淀粉样物质沉积，偏光显微镜下呈现典型的绿色双折射，免疫组织化学显示无细胞角蛋白、AL 和 AA 淀粉样物质反应性，同时病例 2 的淀粉样物质对牙源性成釉细胞瘤相关蛋白（以前称为 APin）呈阳性反应。总之，两只猫都患有产生淀粉样物质的牙源性肿瘤，但它们的肿瘤在形态和产生的淀粉样物质类型上存在差异。
