Department of Nuclear Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Dongcheng District, Beijing, People's Republic of China.
Clin Nucl Med. 2011 Mar;36(3):178-82. doi: 10.1097/RLU.0b013e318208f103.
Three patients with known lung cancer came on different days to our department to have a bone scan to evaluate possible osseous metastatic disease. The bone scan images showed increased Tc-99m methylene diphosphonate (Tc-99m MDP) activity in the liver and to a lesser degree in the spleen, whereas bone scan images from other patients on the same days showed no abnormal activity in the liver or spleen. On the same day, shortly before the bone scan, all 3 patients had a magnetic resonance imaging scan with an intravenous injection of Magnevist (Gadolinium-DTPA), which was not previously known to cause an altered Tc-99m MDP distribution. In the follow-up bone scans performed within 1 week of the initial bone scintigraphy, images from none of these 3 patients showed abnormal liver or spleen activity. The findings indicated that the increased Tc-99m MDP activity in the liver and spleen in the early studies was indeed an effect of Gadolinium-containing magnetic resonance imaging contrast. This effect was further confirmed by an animal experiment.
三位已知患有肺癌的患者分别于不同日期到我科进行骨扫描，以评估可能存在的骨转移疾病。骨扫描图像显示肝脏 Tc-99m 亚甲基二膦酸盐（Tc-99m MDP）活性增加，程度较轻的脾脏也有增加，而同期其他患者的骨扫描图像显示肝脏或脾脏无异常活性。同日，在进行骨扫描前不久，这 3 位患者均进行了静脉注射马根维显（钆喷酸葡胺）的磁共振成像扫描，此前已知这种造影剂不会改变 Tc-99m MDP 的分布。在初始骨闪烁扫描后 1 周内进行的后续骨扫描中，这 3 位患者的图像均未显示肝脏或脾脏活性异常。这些发现表明，早期研究中肝脏和脾脏 Tc-99m MDP 活性增加确实是含钆磁共振成像对比剂的作用。动物实验进一步证实了这一效应。
