甘露醇对脑损伤后脑血流量的短暂影响。

Transient effect on mannitol on cerebral blood flow following brain injury.

作者信息

Shalmon E, Reichenthal E, Kaspi T

机构信息

Department of Neurosurgery, Experimental Research Laboratory, Beilinson Medical Center, Petah Tiqva, Israel.

出版信息

Acta Neurochir Suppl (Wien). 1990;51:116-7. doi: 10.1007/978-3-7091-9115-6_39.

DOI:10.1007/978-3-7091-9115-6_39

PMID:2128573

Abstract

CBF and ICP were measured in cats following cerebral cold injury and mannitol infusion. Mannitol was found to reduce the intracranial hypertension caused by the injury. The restoration of CBF and ICP was of short duration and was followed by a reduction of CBF and elevation of ICP. A repeated restoration of CBF by a second dose of mannitol was followed by a more severe impairment of CBF. The prolonged beneficial effect of mannitol on CBF after brain injury has to be reassessed.

摘要

在猫脑冷损伤及输注甘露醇后，测量其脑血流量（CBF）和颅内压（ICP）。发现甘露醇可减轻损伤所致的颅内高压。CBF和ICP的恢复持续时间较短，随后CBF降低，ICP升高。第二次给予甘露醇使CBF再次恢复后，CBF出现更严重的损害。脑损伤后甘露醇对CBF的长期有益作用必须重新评估。