Ikeda Y, Long D M
Department of Neurosurgery, Nippon Medical School, Tokyo, Japan.
Acta Neurochir Suppl (Wien). 1990;51:68-70. doi: 10.1007/978-3-7091-9115-6_23.
The abstract BW755C is a novel non-steroidal anti-inflammatory agent. It inhibits synthesis of prostaglandins and leukotrienes by inhibition in the cyclooxygenase and lipoxygenase pathways of arachidonic acid metabolism. Cold injury induced vasogenic oedema was produced in 18 cats. The animals were sacrificed at six and twenty-four hours. One group was treated with BW755C. Seventeen white rabbits bearing an experimental brain tumour VX-2 carcinoma were treated for five consecutive days from the eight day after tumour injection to the thirteenth day. Untreated tumour bearing rabbits were used as control. Brain water content was measured by specific gravity method. BW755C did not reduce the water content following cold injury. There was no effect upon peritumoural oedema. The use of this novel blocking agent with diffuse effects in the arachidonic cascade was not beneficial for the reduction or prevention of brain oedema.
摘要 BW755C 是一种新型非甾体抗炎药。它通过抑制花生四烯酸代谢的环氧合酶和脂氧合酶途径来抑制前列腺素和白三烯的合成。对18只猫造成冷损伤诱导的血管源性水肿。在6小时和24小时时处死动物。一组用BW755C治疗。17只携带实验性脑肿瘤VX - 2癌的白兔从肿瘤注射后第8天至第13天连续治疗5天。未治疗的荷瘤兔用作对照。采用比重法测量脑含水量。BW755C不能降低冷损伤后的含水量。对肿瘤周围水肿没有影响。这种在花生四烯酸级联反应中具有广泛作用的新型阻断剂对减轻或预防脑水肿并无益处。
