Gastroenterology Service, Complexo Hospitalario Universitario de A Coruña, Spain.
Eur J Gastroenterol Hepatol. 2011 Mar;23(3):286-8. doi: 10.1097/MEG.0b013e328344042d.
Palmoplantar tylosis is a focal nonepidermolytic palmoplantar hyperkeratosis, which is inherited as an autosomal dominant condition. Two types have been described: an early onset type B tylosis, which occurs in the first year of life and is usually benign, and type A tylosis, which occurs between the ages of 5 and 15 years. Type A tylosis has been associated with a high incidence of oesophageal carcinoma in three families in England, Germany and the USA. This study describes an additional family from Spain with tylosis A, without any known relation to those described before.
掌跖过度角化症是一种局灶性非大疱性掌跖过度角化症，呈常染色体显性遗传。有两种类型：早发型 B 型过度角化症，发生于生命的第一年，通常为良性；A型过度角化症，发生于 5 至 15 岁之间。A型过度角化症与英格兰、德国和美国的三个家庭的食管癌高发率有关。本研究描述了来自西班牙的另一个 A 型过度角化症家族，与以前描述的家族没有任何已知的关系。
