教育与乳腺癌的关联在双胞胎中是否存在重复？一项基于丹麦女性双胞胎的登记研究。
Does the association of education with breast cancer replicate within twin pairs? A register-based study on Danish female twins.
机构信息
Unit of Epidemiology, University of Southern Denmark, The Danish Twin Registry, DARC, University of Southern Denmark.
出版信息
Br J Cancer. 2011 Feb 1;104(3):520-3. doi: 10.1038/sj.bjc.6606090.
Abstract
BACKGROUND
A positive association between socio-economic position and breast cancer has been widely observed, but not hitherto within twin pairs, where shared familial factors were adjusted for.
METHODS
We used data on education and other factors from the Danish Twin Registry, The Danish Cancer Registry, and official registers on a total of 16 310 twins. Unpaired and intrapair Cox regression analyses were compared.
RESULTS
In the unpaired analysis, an educational gradient in breast cancer risk was found. Similar results were seen in the intrapair analyses of all twins, although no longer statistically significant. When intrapair analyses were stratified on zygosity, the effect of education was attenuated in the monozygotic twins.
CONCLUSION
The main findings support an effect of education beyond shared familial factors.
摘要
背景
社会经济地位与乳腺癌之间呈正相关，这一关联已得到广泛观察，但在双胞胎中尚未观察到，因为双胞胎中调整了共同的家庭因素。
方法
我们使用了丹麦双胞胎登记处、丹麦癌症登记处和关于总共 16310 对双胞胎的官方登记处的教育和其他因素的数据。我们比较了非配对和配对 Cox 回归分析。
结果
在非配对分析中，发现乳腺癌风险存在教育梯度。在所有双胞胎的配对分析中也观察到了类似的结果，尽管不再具有统计学意义。当按同卵双生子和异卵双生子进行配对分析分层时，教育的作用在同卵双生子中减弱。
结论
主要发现支持教育对共同家庭因素之外的乳腺癌发病风险的影响。
相似文献
1
Does the association of education with breast cancer replicate within twin pairs? A register-based study on Danish female twins.教育与乳腺癌的关联在双胞胎中是否存在重复？一项基于丹麦女性双胞胎的登记研究。
Br J Cancer. 2011 Feb 1;104(3):520-3. doi: 10.1038/sj.bjc.6606090.
2
Are familial factors underlying the association between socioeconomic position and prescription medicine? A register-based study on Danish twins.家庭因素是否是社会经济地位与处方药使用之间关联的基础？基于丹麦双胞胎的登记研究。
BMJ Open. 2013 Nov 12;3(11):e003292. doi: 10.1136/bmjopen-2013-003292.
3
Does educational status impact adult mortality in Denmark? A twin approach.教育程度是否会影响丹麦成年人的死亡率？一项双胞胎研究。
Am J Epidemiol. 2010 Jul 15;172(2):225-34. doi: 10.1093/aje/kwq072. Epub 2010 Jun 7.
4
Sex differences in risk and heritability estimates on primary knee osteoarthritis leading to total knee arthroplasty: a nationwide population based follow up study in Danish twins.导致全膝关节置换术的原发性膝关节骨关节炎风险及遗传度估计中的性别差异：丹麦双胞胎基于全国人口的随访研究
Arthritis Res Ther. 2016 Feb 11;18:46. doi: 10.1186/s13075-016-0939-8.
5
Evidence of a genetic factor in migraine with aura: a population-based Danish twin study.伴先兆偏头痛中遗传因素的证据：一项基于丹麦人群的双胞胎研究。
Ann Neurol. 1999 Feb;45(2):242-6. doi: 10.1002/1531-8249(199902)45:2<242::aid-ana15>3.0.co;2-1.
6
Are the educational differences in incidence of cardiovascular disease explained by underlying familial factors? A twin study.心血管疾病发病率的教育差异是否可以通过潜在的家族因素来解释？一项双胞胎研究。
Soc Sci Med. 2014 Oct;118:182-90. doi: 10.1016/j.socscimed.2014.04.016. Epub 2014 Apr 15.
7
Concordance Rates of Adolescent Idiopathic Scoliosis in a Danish Twin Population.丹麦双胞胎人群中青少年特发性脊柱侧凸的一致性率
Spine (Phila Pa 1976). 2016 Oct 1;41(19):1503-1507. doi: 10.1097/BRS.0000000000001681.
8
Cancer in twins: genetic and nongenetic familial risk factors.双胞胎中的癌症：遗传和非遗传家族风险因素。
J Natl Cancer Inst. 1997 Feb 19;89(4):287-93. doi: 10.1093/jnci/89.4.287.
9
Concordance of autoimmune disease in a nationwide Danish systemic lupus erythematosus twin cohort.全国性丹麦系统性红斑狼疮双胞胎队列中自身免疫性疾病的一致性。
Semin Arthritis Rheum. 2018 Feb;47(4):538-544. doi: 10.1016/j.semarthrit.2017.06.007. Epub 2017 Jun 23.
10
The Danish Twin Registry: An Updated Overview.丹麦双胞胎登记处：最新概述。
Twin Res Hum Genet. 2019 Dec;22(6):499-507. doi: 10.1017/thg.2019.72. Epub 2019 Sep 23.
引用本文的文献
1
Another casualty of sibling fixed-effects analysis of education and health: an informative null, or null information?教育与健康的兄弟姐妹固定效应分析的又一牺牲品：一个有信息的零假设，还是零信息？
Soc Sci Med. 2014 Oct;118:191-3. doi: 10.1016/j.socscimed.2014.06.029. Epub 2014 Jun 21.
2
Are familial factors underlying the association between socioeconomic position and prescription medicine? A register-based study on Danish twins.家庭因素是否是社会经济地位与处方药使用之间关联的基础？基于丹麦双胞胎的登记研究。
BMJ Open. 2013 Nov 12;3(11):e003292. doi: 10.1136/bmjopen-2013-003292.
3
Matched survival data in a co-twin control design.同卵双胞胎对照设计中的匹配生存数据。
Lifetime Data Anal. 2014 Jan;20(1):38-50. doi: 10.1007/s10985-013-9256-6. Epub 2013 Jul 18.
4
Social inequality in breast, lung and colorectal cancers: a sibling approach.乳腺癌、肺癌和结直肠癌的社会不平等：同胞研究方法。
BMJ Open. 2013 Mar 15;3(3):e002114. doi: 10.1136/bmjopen-2012-002114.
5
Cancer and longevity--is there a trade-off? A study of cooccurrence in Danish twin pairs born 1900-1918.癌症与长寿——是否存在权衡关系？对丹麦出生于 1900-1918 年的双胞胎的共同发生情况的研究。
J Gerontol A Biol Sci Med Sci. 2012 May;67(5):489-94. doi: 10.1093/gerona/gls087. Epub 2012 Apr 3.
本文引用的文献
1
Does educational status impact adult mortality in Denmark? A twin approach.教育程度是否会影响丹麦成年人的死亡率？一项双胞胎研究。
Am J Epidemiol. 2010 Jul 15;172(2):225-34. doi: 10.1093/aje/kwq072. Epub 2010 Jun 7.
2
Alcohol consumption and breast cancer risk.饮酒与乳腺癌风险。
Breast Cancer Res. 2009;11 Suppl 3(Suppl 3):S3. doi: 10.1186/bcr2422. Epub 2009 Dec 18.
3
Birth weight-breast cancer revisited: is the association confounded by familial factors?出生体重与乳腺癌关系再探讨：这种关联是否受家族因素混淆？
Cancer Epidemiol Biomarkers Prev. 2009 Sep;18(9):2447-52. doi: 10.1158/1055-9965.EPI-09-0123. Epub 2009 Aug 18.
4
Birth size and breast cancer risk: re-analysis of individual participant data from 32 studies.出生体重与乳腺癌风险：对32项研究的个体参与者数据的重新分析。
PLoS Med. 2008 Sep 30;5(9):e193. doi: 10.1371/journal.pmed.0050193.
5
Social inequality and incidence of and survival from breast cancer in a population-based study in Denmark, 1994-2003.1994 - 2003年丹麦一项基于人群的研究中社会不平等与乳腺癌发病率及生存率的关系
Eur J Cancer. 2008 Sep;44(14):1996-2002. doi: 10.1016/j.ejca.2008.06.027. Epub 2008 Aug 11.
6
Childhood social class and cancer incidence: results of the globe study.儿童社会阶层与癌症发病率：全球研究结果
Soc Sci Med. 2008 Mar;66(5):1131-9. doi: 10.1016/j.socscimed.2007.11.035.
7
Estimates of the cancer incidence and mortality in Europe in 2006.2006年欧洲癌症发病率和死亡率的估计数据。
Ann Oncol. 2007 Mar;18(3):581-92. doi: 10.1093/annonc/mdl498. Epub 2007 Feb 7.
8
Reproductive factors and breast cancer risk according to joint estrogen and progesterone receptor status: a meta-analysis of epidemiological studies.根据雌激素和孕激素受体联合状态分析生殖因素与乳腺癌风险：一项流行病学研究的荟萃分析
Breast Cancer Res. 2006;8(4):R43. doi: 10.1186/bcr1525.
9
Preschool diet and adult risk of breast cancer.学龄前饮食与成人患乳腺癌风险
Int J Cancer. 2006 Feb 1;118(3):749-54. doi: 10.1002/ijc.21407.
10
A life course approach to chronic disease epidemiology.慢性病流行病学的生命历程研究方法。
Annu Rev Public Health. 2005;26:1-35. doi: 10.1146/annurev.publhealth.26.021304.144505.
Zotero 插件