Ausina V, García-Barceló M, Luquin M, Belda F, Fernández J, Esteban G, Sauret J, Mirelis B, Prats G
Departamento de Microbiología, Hospital de la Santa Creu i Sant Pau, Barcelona.
Enferm Infecc Microbiol Clin. 1990 May;8(5):274-7.
From july 1982 to december 1987 we prospectively evaluated the primary resistance (PR) of 248 strains of M. tuberculosis isolated from patients with several clinical forms of tuberculosis. The results were compared with those of a similar study carried out between 1978-1982. PR persisted relatively stable with time, although it showed a trend towards reduction. Isoniazide resistance (4.8%) still has a leading epidemiological interest. The 89% of strains showed isolated resistance to a single drug. Only two strains had associated resistance to INH and SM. Strains with PR to RIF, ETB or PZA were not detected. Of the 248 evaluated strains, 32 were isolated from intravenous drug abusers with AIDS. Only one of these strains had a low level (0.2 mg/l) PR to INH. At last two of these drug abusers developed acquired resistance to INH and ETB-RIF, respectively. Considering the difficulty to control chemotherapy in this group of patients, our finding has a considerable epidemiological interest.
1982年7月至1987年12月，我们对从患有多种临床类型结核病的患者中分离出的248株结核分枝杆菌的原发性耐药性（PR）进行了前瞻性评估。将结果与1978 - 1982年间进行的一项类似研究的结果进行了比较。PR随时间相对保持稳定，尽管呈下降趋势。异烟肼耐药率（4.8%）仍然具有主要的流行病学意义。89%的菌株仅对单一药物耐药。仅有两株菌株对异烟肼和链霉素具有联合耐药性。未检测到对利福平、乙硫异烟胺或吡嗪酰胺有原发性耐药的菌株。在评估的248株菌株中，有32株是从患有艾滋病的静脉吸毒者中分离出来的。这些菌株中只有一株对异烟肼有低水平（0.2mg/l）的原发性耐药。最后，这些吸毒者中有两人分别对异烟肼和乙硫异烟胺 - 利福平产生了获得性耐药。考虑到在这组患者中控制化疗的困难，我们的发现具有相当大的流行病学意义。
