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长 QT 综合征诱发全身麻醉诱导 - 病例报告 - 。

Long QT syndrome provoked by induction of general anesthesia -A case report-.

机构信息

Department of Anesthesiology and Pain Medicine, Presbyterian Medical Center, Jeonju, Korea.

出版信息

Korean J Anesthesiol. 2010 Dec;59 Suppl(Suppl):S114-8. doi: 10.4097/kjae.2010.59.S.S114. Epub 2010 Dec 31.

DOI:10.4097/kjae.2010.59.S.S114
PMID:21286418
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3030014/
Abstract

Long QT syndrome (LQTS) is an arrhythmogenic cardiovascular disorder resulting from mutations in cardiac ion channels. LQTS is characterized by prolonged ventricular repolarization and frequently manifests itself as QT interval prolongation on the electrocardiogram (ECG). A variety of commonly prescribed anesthetic drugs possess the adverse property of prolonging cardiac repolarization and may provoke serious ventricular tachyarrhythmia called 'torsades de pointes', ventricular fibrillation, and sudden death. We experienced a case of ventricular tachycardia and ventricular fibrillation after anesthetic induction and it came out into the open that anesthetic induction provoked long QT syndrome.

摘要

长 QT 综合征(LQTS)是一种由心脏离子通道基因突变引起的心律失常性心血管疾病。LQTS 的特征是心室复极延长,常表现为心电图(ECG)上 QT 间期延长。许多常用的麻醉药物具有延长心脏复极的不良特性,可能引发严重的室性心动过速,称为尖端扭转型室性心动过速、心室颤动和猝死。我们曾遇到一例麻醉诱导后出现室性心动过速和心室颤动的病例,结果发现麻醉诱导引发了长 QT 综合征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baab/3030014/abf7ce8d21ba/kjae-59-S114-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baab/3030014/abf7ce8d21ba/kjae-59-S114-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baab/3030014/abf7ce8d21ba/kjae-59-S114-g001.jpg

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引用本文的文献

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Perioperative torsade de pointes: a systematic review of published case reports.围手术期尖端扭转型室性心动过速:已发表病例报告的系统评价。
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3
Drugs to be avoided in patients with long QT syndrome: Focus on the anaesthesiological management.长QT综合征患者应避免使用的药物:关注麻醉管理。

本文引用的文献

1
Recent progress in congenital long QT syndrome.先天性长 QT 综合征的最新进展。
Curr Opin Cardiol. 2010 May;25(3):216-21. doi: 10.1097/HCO.0b013e32833846b3.
2
Long QT syndrome: from channels to cardiac arrhythmias.长QT综合征:从离子通道到心律失常
J Clin Invest. 2005 Aug;115(8):2018-24. doi: 10.1172/JCI25537.
3
The effects of sevoflurane, isoflurane and desflurane on QT interval of the ECG.七氟烷、异氟烷和地氟烷对心电图QT间期的影响。
World J Cardiol. 2013 Apr 26;5(4):87-93. doi: 10.4330/wjc.v5.i4.87.
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QT interval abnormalities: risk factors and perioperative management in long QT syndromes and Torsades de Pointes.QT 间期异常:长 QT 综合征和尖端扭转型室性心动过速的危险因素和围手术期管理。
J Anesth. 2013 Aug;27(4):575-87. doi: 10.1007/s00540-013-1564-1. Epub 2013 Feb 15.
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Long QT syndrome and anaesthesia.长QT综合征与麻醉
Eur J Anaesthesiol. 2002 Dec;19(12):853-9. doi: 10.1017/s0265021502001370.
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Congenital Long QT syndrome.先天性长QT综合征
Card Electrophysiol Rev. 2002 Feb;6(1-2):57-60. doi: 10.1023/a:1017935121656.
6
Is there a role for implantable cardioverter defibrillators in long QT syndrome?植入式心脏复律除颤器在长QT综合征中是否有作用?
J Cardiovasc Electrophysiol. 2002 Jan;13(1 Suppl):S110-3.
7
Electrocardiographic prediction of abnormal genotype in congenital long QT syndrome: experience in 101 related family members.先天性长QT综合征异常基因型的心电图预测:101名相关家庭成员的经验
J Cardiovasc Electrophysiol. 2001 Apr;12(4):455-61. doi: 10.1046/j.1540-8167.2001.00455.x.
8
Pharmacogenetics of cardiac K(+) channels.心脏钾通道的药物遗传学
Eur J Pharmacol. 2000 Dec 27;410(2-3):281-287. doi: 10.1016/s0014-2999(00)00821-9.
9
Effects of four anticholinesterase-anticholinergic combinations and tracheal extubation on QTc interval of the ECG, heart rate and arterial pressure.四种抗胆碱酯酶-抗胆碱能药物组合及气管拔管对心电图QTc间期、心率和动脉压的影响。
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10
The effects of midazolam or propofol followed by suxamethonium on the QT interval in humans.咪达唑仑或丙泊酚后接琥珀胆碱对人体QT间期的影响。
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