Moss Arthur J, Kass Robert S
Heart Research Follow-up Program, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.
J Clin Invest. 2005 Aug;115(8):2018-24. doi: 10.1172/JCI25537.
Long QT syndrome, a rare genetic disorder associated with life-threatening arrhythmias, has provided a wealth of information about fundamental mechanisms underlying human cardiac electrophysiology that has come about because of truly collaborative interactions between clinical and basic scientists. Our understanding of the mechanisms that control the critical plateau and repolarization phases of the human ventricular action potential has been raised to new levels through these studies, which have clarified the manner in which both potassium and sodium channels regulate this critical period of electrical activity.
长QT综合征是一种与危及生命的心律失常相关的罕见遗传疾病，它提供了大量有关人类心脏电生理学基本机制的信息，这些信息源于临床科学家和基础科学家之间真正的合作互动。通过这些研究，我们对控制人类心室动作电位关键平台期和复极期机制的理解提升到了新的水平，这些研究阐明了钾通道和钠通道调节这一关键电活动时期的方式。
