Department of Chemistry, National Taiwan Normal University, 88, Section 4, Tingchow Road, Taipei 11677, Taiwan, Republic of China.
Org Biomol Chem. 2011 Apr 7;9(7):2098-106. doi: 10.1039/c0ob00912a. Epub 2011 Feb 1.
An efficient and mild synthesis of trisubstituted furans, starting from α,β-unsaturated ketones, tributylphosphine, and acyl chlorides, is described. The strategy employs the intramolecular Wittig protocol as a key step to install the crucial furan ring, leading to a wide variety of highly functional furans in one step.
本文描述了一种从α,β-不饱和酮、三丁基膦和酰氯出发，高效、温和合成三取代呋喃的方法。该策略采用分子内Wittig 反应作为关键步骤来构建关键的呋喃环，一步即可得到多种高官能度的呋喃。
