HIV 感染及相关脑损伤中的丝裂原活化蛋白激酶 p38。
Mitogen-activated protein kinase p38 in HIV infection and associated brain injury.
机构信息
Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
出版信息
J Neuroimmune Pharmacol. 2011 Jun;6(2):202-15. doi: 10.1007/s11481-011-9260-0. Epub 2011 Feb 1.
Abstract
Infection with human immunodeficiency virus-1 (HIV-1) often leads to HIV-associated neurocognitive disorders (HAND) prior to the progression to acquired immunodeficiency syndrome (AIDS). At the cellular level, mitogen-activated protein kinases (MAPK) provide a family of signal transducers that regulate many processes in response to extracellular stimuli and environmental stress, such as viral infection. Recently, evidence has accumulated suggesting that p38 MAPK plays crucial roles in various pathological processes associated with HIV infection, ranging from macrophage activation to neurotoxicity and impairment of neurogenesis to lymphocyte apoptosis. Thus, p38 MAPK, which has generally been linked to stress-related signal transduction, may be an important mediator in the development of AIDS and HAND.
摘要
人类免疫缺陷病毒 1（HIV-1）感染常导致 HIV 相关神经认知障碍（HAND），然后发展为获得性免疫缺陷综合征（AIDS）。在细胞水平上，丝裂原活化蛋白激酶（MAPK）提供了一个信号转导家族，可调节对细胞外刺激和环境应激（如病毒感染）的多种反应过程。最近，有证据表明 p38 MAPK 在与 HIV 感染相关的各种病理过程中发挥着至关重要的作用，范围从巨噬细胞激活到神经毒性和神经发生受损到淋巴细胞凋亡。因此，p38 MAPK 通常与应激相关的信号转导有关，它可能是 AIDS 和 HAND 发展的重要介质。
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