腹侧去甲肾上腺素能束的损伤可阻止大鼠因社会剥夺应激而引起的血压升高。
Lesions of the ventral noradrenergic bundle prevent the rise in blood pressure induced by social deprivation stress in the rat.
作者信息
Montero S, Fuentes J A, Fernandez-Tome P
机构信息
Institute of Pharmacology and Toxicology (CSIC) School of Medicine, Universidad Complutense, Madrid, Spain.
出版信息
Cell Mol Neurobiol. 1990 Dec;10(4):497-505. doi: 10.1007/BF00712844.
Abstract
- Hypertension can be induced by some types of stress in the rat. The aim of the present work was to study the putative implication of brain norepinephrine (NE) in blood pressure increase due to social deprivation stress. 2. The effects of 6-hydroxydopamine (6-OHDA) lesions of the ventral noradrenergic bundle (VNEB) on the hypertensive response induced by brief social deprivation stress in young Wistar rats were examined. NE, dopamine (DA), and epinephrine (EPI) levels were measured by HPLC coupled with electrochemical detection in two brain areas (hypothalamus and medulla oblongata) relevant for blood pressure regulation. 3. VNEB lesions prevented the hypertensive response produced by isolation. Twelve or 20 days after 6-OHDA administration, NE and EPI but not DA levels decreased in the hypothalamus of the lesioned rats. In contrast, no catecholamine changes were detected in medulla oblongata. 4. These data suggest that the VNEB plays a role in the triggering of the hypertensive response induced by social deprivation stress in young Wistar rats.
摘要
- 在大鼠中，某些类型的应激可诱发高血压。本研究的目的是探讨脑去甲肾上腺素（NE）在社会剥夺应激导致血压升高过程中的潜在作用。2. 研究了腹侧去甲肾上腺素能束（VNEB）的6-羟基多巴胺（6-OHDA）损伤对幼年Wistar大鼠短暂社会剥夺应激诱发的高血压反应的影响。采用高效液相色谱结合电化学检测法，测定了与血压调节相关的两个脑区（下丘脑和延髓）中的去甲肾上腺素（NE）、多巴胺（DA）和肾上腺素（EPI）水平。3. VNEB损伤可预防隔离引起的高血压反应。给予6-OHDA 12或20天后，损伤大鼠下丘脑内的NE和EPI水平降低，但DA水平未降低。相比之下，延髓中未检测到儿茶酚胺变化。4. 这些数据表明，VNEB在幼年Wistar大鼠社会剥夺应激诱发的高血压反应触发中起作用。
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