韩国多系统萎缩症患者的存活率。

Survival of Korean patients with multiple system atrophy.

机构信息

Departments of Neurology and Movement Disorder Center and Neuroscience Research Institute, BK21, College of Medicine, Seoul National University, Seoul, Korea.

出版信息

Mov Disord. 2011 Apr;26(5):909-12. doi: 10.1002/mds.23580. Epub 2011 Feb 1.

DOI:10.1002/mds.23580

PMID:21287601

Abstract

METHODS

We conducted a retrospective medical record review to determine the survival of 455 Korean multiple system atrophy (MSA) patients and examined the effect of clinical factors that could possibly influence survival. The patients comprised 222 men and 233 women.

RESULTS

Age at onset was 60.1 ± 8.8 years (mean ± SD) and did not differ between the sexes. Parkinsonism was the most prevalent initial symptom, followed by cerebellar dysfunction and dysautonomia. Age at onset was significantly older in patients with predominant parkinsonism at the last visit (MSA-P) than in the other patients. At the time of data collection, 107 patients had died. Median survival time was 10 years. The survival rate of women was slightly better than that of men, especially in MSA-P patients.

CONCLUSIONS

Survival was not affected by age at onset, initial symptom, or predominant symptom at the last visit or by the presence of autonomic symptoms or multiple symptoms at disease onset.

摘要

方法

我们进行了一项回顾性病历审查，以确定 455 名韩国多系统萎缩（MSA）患者的生存率，并检查了可能影响生存的临床因素的影响。这些患者包括 222 名男性和 233 名女性。

结果

发病年龄为 60.1 ± 8.8 岁（平均值 ± 标准差），男女之间无差异。帕金森病是最常见的首发症状，其次是小脑功能障碍和自主神经功能障碍。在最后一次就诊时，以帕金森病为主的患者的发病年龄明显大于其他患者。在数据收集时，107 名患者已经死亡。中位生存时间为 10 年。女性的生存率略好于男性，尤其是在以帕金森病为主的患者中。