Department of Neurology B and Neurogenetics, hôpital des spécialités O.N.O, Rabat-Instituts, avenue Mohammed-Belarbi-El-Alaoui, BP 6444, Rabat, Morocco.
Rev Neurol (Paris). 2013 Feb;169(2):121-5. doi: 10.1016/j.neurol.2012.04.006. Epub 2012 Jul 2.
Multiple system atrophy (MSA) is a sporadic and rapidly progressive neurodegenerative disorder of poor prognosis, characterised clinically by any combination of parkinsonian, autonomic, cerebellar, or pyramidal signs. We report our experience in movement disorders consultation concerning the clinical presentation and the course of MSA in Moroccan patients.
A retrospective review of the medical records of 17 patients with diagnosis of MSA seen in our outpatient clinic from January 2007 to December 2010.
In our 17 patients, 76.5% were men and the mean age of onset was 52±9 years. MSA-P was the major clinical phenotype (82.4%). Eleven patients (64.7%) were classified as having probable MSA and six patients (35.3%) as possible MSA. Dysautonomic features were detected in all patients; urinary symptoms were found in 76.5% of cases and orthostatic hypotension in 64.7%. Treatment regimen included l-Dopa with a mean daily dose of 621.4±346.8mg/day and symptomatic treatment of dysautonomia. The mean duration of disease evolution was of 4.7±1.9 years.
Our results show a male predominance and an early age of disease onset. MSA-P was the predominant subtype. Our results are similar to the European MSA series.
Multicentre studies are needed to better characterise MSA in Morocco given the rarity of this disease.
多系统萎缩（MSA）是一种散发性、进行性神经退行性疾病，预后不良，临床上以帕金森、自主神经、小脑或锥体束征的任意组合为特征。我们报告了我们在运动障碍咨询方面的经验，涉及 MSA 在摩洛哥患者中的临床表现和病程。
对 2007 年 1 月至 2010 年 12 月在我们门诊就诊的 17 例 MSA 患者的病历进行回顾性分析。
在我们的 17 例患者中，76.5%为男性，平均发病年龄为 52±9 岁。MSA-P 是主要的临床表型（82.4%）。11 例（64.7%）患者被归类为可能 MSA，6 例（35.3%）患者被归类为可疑 MSA。所有患者均存在自主神经功能障碍特征；76.5%的病例存在排尿症状，64.7%的病例存在体位性低血压。治疗方案包括 l-多巴，平均日剂量为 621.4±346.8mg/天，以及自主神经功能障碍的对症治疗。疾病进展的平均持续时间为 4.7±1.9 年。
我们的结果显示男性患病率较高，发病年龄较早。MSA-P 是主要亚型。我们的结果与欧洲 MSA 系列相似。
鉴于这种疾病的罕见性，需要进行多中心研究以更好地描述摩洛哥的 MSA。
